文献类型：期刊文献

中文题名：细胞毒素相关蛋白A与特发性血小板减少性紫癜相关性研究

英文题名：The study on the relationship between Cytotoxin associated protein A and Idiopathic Thrombocytopenia Purpura

作者：雷瑚仪[1];张子彦[1]

机构：[1]绍兴文理学院附属医院血液内科

年份：2012

卷号：22

期号：15

起止页码：54

中文期刊名：中国现代医学杂志

外文期刊名：China Journal of Modern Medicine

收录：CSTPCD、、北大核心2011、CSCD_E2011_2012、北大核心、CSCD

语种：中文

中文关键词：细胞毒素相关蛋白A;幽门螺杆菌;血小板相关抗体;特发性血小板减少性紫癜

外文关键词：cytotoxin-associated protein A； helicobacter pylori； PA-IgG； idiopathic thrombocytopenia purpura

中文摘要：目的幽门螺杆菌(Hp)可能通过细胞毒素相关蛋白A(cagA)参与特发性血小板减少性紫癜(ITP)发病。比较ITP患者不同血小板分组血小板抗体IgG(PA-IgG)、CagA定量,Hp、CagA阳性率,探索CagA与ITP相关性。方法 ITP组(93例)总体Hp、cagA阳性率与健康组(49例)、非血液系统疾病血小板减少组(55例)比较。ITP组按血小板数值分为PLT≤20×109/L,20×109/L0.05。ITP三组间PA-IgG、CagA定量,CagA阳性率比较,血小板低组,PA-IgG、CagA定量,cagA阳性率高,差异有显著性,P<0.05;50×109/L≤PLT组Hp阳性率明显低于PLT≤20×109/L组,P<0.05;PLT≤20×109/L组与20×109/L0.05。结论 Hp参与ITP发病,ITP血小板计数与Hp感染率不完全一致,与PA-IgG、cagA存在相关性。提示,HP可能因CagA致PA-IgG升高,导致血小板降低。

外文摘要：【Objective】 Helicobacter Pylori（Hp） involved in pathogenesis of Idiopathic Thrombocytopenic Purpur（ITP） by Cytotoxin associated protein A（cagA）.According to the platelet values,ITP patients were divided into three groups.Through the comparison between the groups PA-IgG,CagA quantitative,Hp,CagA-positive rate,to explore the relation between Cytotoxin associated protein A and ITP.【Methods】 contrast Hp and cagA-positive rate of 93 patients with ITP and health group（49 cases）,non-hematological diseases platelets less Group（55 cases）.To give 93 patients with ITP,divide them into three groups： PLT≤20×109/L,20×109/L〈PLT〈50×109/L,50×109/L≤PLT.Rapid urease test（RUT） and 14C urea breath test（UBT） is detected by Hp.Enzyme linked immunosorbent assay method survey the PA-IgG and the cagA levels of ITP patients.It is quantitative comparisons between groups of patients with ITP PA-IgG,cagA and Hp,cagA-positive rate.【Results】 Hp,cagA-positive rate of the ITP group are significantly higher than the health group and the non-blood diseases platelets less group（P 〈0.05）;Hp,cagA-positive rate of the health group are not significantly different with the non-blood diseases platelets less group（P 〉0.05）.For patients with ITP,Lower platelet group,PA-IgG,CagA quantitative and cagA-positive rate are higher,Comparative differences between the groups significantly（P 〈0.05）;The Hp positive rate of the 50×109/L≤PLT group is significantly blower than the PLT≤20×109/L group（P 〈0.05）;The Hp positive rate is not significant difference between PLT≤20×109/L group and 20×109/L〈PLT〈50×109/L group,between 20×109/L〈PLT〈50×109/L group and 50×109/L≤PLT group（P 〉0.05）.【Conclusion】 Hp involved in pathogenesis of ITP.ITP patient platelet count and Hp infection rate is not entirely consistent.The correlation exists in ITP patient platelet count and PA-IgG,cagA.HP may induce the rise of PA-IgG by CagA that Leads to ITP patient’s platelet reduce.