文献类型：期刊文献

英文题名：Communications Among Neurocytes in Parkinson's Disease Regulated by Differential Metabolism and Blood-Brain Barrier Traversing of Chiral Gold Cluster-MOF Integrated Nanoparticles

作者：Chen, Junyang[1];Xu, Gaoxiang[2];Shen, Runpu[3];Xu, Jianzhong[2];Lu, Congcong[4];Li, Xin[4];Feng, Qi[4,5];Li, Qing[4]

机构：[1]Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Peoples R China;[2]Zhengzhou Univ, Affiliated Hosp 1, Dept Orthoped, Zhengzhou 450052, Peoples R China;[3]Shaoxing Univ, Coll Chem & Chem Engn, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Shaoxing 312000, Peoples R China;[4]Zhengzhou Univ, Affiliated Hosp 2, Dept Neurol, Zhengzhou 450052, Peoples R China;[5]Zhengzhou Univ, Affiliated Hosp 1, Dept Nephrol, Zhengzhou 450052, Peoples R China

年份：2025

外文期刊名：ADVANCED SCIENCE

收录：SCI-EXPANDED(收录号：WOS:001487910000001)、、EI(收录号：20252118452668)、Scopus(收录号：2-s2.0-105005269972)、WOS

基金：J.C. and G.X. contributed equally to this work. This work was financially supported by the National Natural Science Foundation of China (32401172, 22278270), the Tackle Key Problems in Science and Technology Project of Henan Province, China (242102311139), the Key Scientific Research Project of Universities in Henan Province (25B310006), and the Joint Co-construction Project of Medical Science and Technology Tackling Program in Henan Province (LHGJ20240248).

语种：英文

外文关键词：energy metabolic reprogramming; neuroinflammation; Parkinson's disease; protein corona; "three-body problem"; ZIF-based chiral nanomedicines

外文摘要：This study have previously reported that ZIF-based chiral nanomedicines achieve Parkinson's disease (PD) therapy through differential metabolism and relief of neuroinflammation. However, lack of overall chirality and anti-inflammatory capacity of nanomedicines limit the further effective solution to the nanobiological effects research in PD. Here, it dexterously loaded chiral gold nanoclusters (AuNCs) onto the inner and outer surfaces of ZIF to achieve the purpose of simultaneously improving the overall chirality and anti-inflammatory activity of the composite nanoparticles (NPs). There are significant differences in the composition of protein corona between different chiral NPs, which elucidates the mechanism of chiral-mediated discrepancies in metabolism and the blood-brain barrier (BBB) traversing. Multi-omics and biochemical techniques further reveal that chiral NPs interfere with the chemokine axis (CX3CL1/CX3CR1)-NF-kappa B-NLRP3 and PI3K-AKT signaling pathways, regulate communications between neurons, neural stem cells and microglia ("the three-body problem"), and induce anti-inflammatory efficacy of microglia mitochondrial energy metabolic reprogramming in PD. The research uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral NPs, providing deep insights into the nanobiological effects of chiral anti-inflammatory nanomedicines in PD therapy for future clinical transformation.