文献类型：期刊文献

中文题名：人胎发育过程中Bcl-2和Bax蛋白在小肠中的表达

英文题名：EXPRESSION OF Bcl-2 AND Bax PROTEINS IN THE DEVELOPING SMALL INTESTINE OF HUMAN FETUS

作者：刘学红[1];张金萍[1];何淑英[2];宋文芳[2]

机构：[1]绍兴文理学院医学院组织学与胚胎学教研室;[2]绍兴市计划生育技术指导站

年份：2007

卷号：38

期号：6

起止页码：755

中文期刊名：解剖学报

外文期刊名：Acta Anatomica Sinica

收录：CSTPCD、、北大核心2004、Scopus、CSCD2011_2012、北大核心、CSCD

语种：中文

中文关键词：小肠;Bcl-2蛋白;Bax蛋白;发育;免疫组织化学;人胎

外文关键词：Small intestine; Bcl-2 protein; Bax protein; Development; Immunohistochemistry; Human fetus

中文摘要：目的探讨人胎小肠发育过程中肠壁细胞增殖与凋亡的变化规律,及相关蛋白B细胞淋巴瘤/白血病-2(Bcl-2)和Bcl相关蛋白(Bax)在小肠生长发育中的表达意义。方法应用免疫组织化学ABC法检测第2、3、4三个月胎龄段,人胎小肠肠壁组织内Bcl-2和Bax蛋白的表达。结果第2、3、4三个月胎龄段,小肠肠壁肌间神经丛和黏膜下神经丛内均有Bcl-2阳性细胞分布,Bax在小肠黏膜层上皮细胞的细胞质内广泛表达。结论Bcl-2/Bax蛋白在人胎小肠的生长发育过程中起重要的调节作用。

外文摘要：Objective To explore the role of cell proliferation and apoptosis, and the expression significance of involved protein as Bcl-2 （B-cell lymphoma/leukemia-2） and Bax （Bcl-associate X protein） in the developing small intestine of human fetus. Methods The expression product of Bcl-2 and Bax was investigated with immunohistochemical methods in the 2nd, 3rd and 4th months of gestation respectively. Results In the second, the third and the fourth month of gestation, the Bcl-2 immunoreactive positive signals were found in the ganglion cells of intermuscular and submucous nerve plexus. Bax positive cells were observed in the cytoplasm of the simple columnar epithelium cells of the small intestinal mucous layer. Conclusion Bcl-2 and Bax proteins regulate the developing small intestine of human fetus.