详细信息
超声微泡携基因治疗肝脏疾病应用进展 被引量:3
Application progresses of ultrasound microbubbles carrying gene in treatment of liver diseases
文献类型:期刊文献
中文题名:超声微泡携基因治疗肝脏疾病应用进展
英文题名:Application progresses of ultrasound microbubbles carrying gene in treatment of liver diseases
作者:席佳达[1];夏国园[1];程祖胜[2]
机构:[1]绍兴文理学院医学院;[2]绍兴市第七人民医院放射科
年份:2018
卷号:34
期号:12
起止页码:1897
中文期刊名:中国医学影像技术
外文期刊名:Chinese Journal of Medical Imaging Technology
收录:CSTPCD、、北大核心2017、Scopus、CSCD2017_2018、北大核心、CSCD
基金:浙江省自然科学基金(Y2110966);浙江省医药卫生研究计划项目A类(2015RYA225);浙江省公益性技术应用研究计划项目(2014C33152)
语种:中文
中文关键词:微泡;造影剂;基因;超声检查;肝
外文关键词:Microbubbles;Contrast media;Genes ;Ultrasonography;Liver
中文摘要:超声靶向微泡破坏技术通过空化效应有效促进外源基因在目的组织中的转染,可通过抑制细胞某些基因的表达或抑制其信号通路而进行基因治疗,使基因治疗各类肝脏疾病逐渐成为可能。本文主要就超声微泡携基因在肝脏疾病中的应用进展进行综述。
外文摘要:Ultrasound-targeted microbubbles destruction can effectively promote transfection of the exogenous gene in target tissue with the cavitation,and inhibit the expression of some genes of cells or inhibit their signaling pathways, thereby achieving the purpose of gene therapy and making the treatment of various liver diseases gradually become possible. The application progresses of ultrasound microbubbles carrying genes in treatment of liver diseases were reviewed in this article.
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