文献类型：期刊文献

英文题名：Role of anti-angiogenic factors in the pathogenesis of breast cancer: A review of therapeutic potential

作者：Ruan, Liwei[1];Zhang, Songou[2];Chen, Xiaozhen[2];Liang, Wenqing[3,5];Xie, Qiong[4,6]

机构：[1]Zhejiang Univ, Shaoxing Peoples Hosp, Shaoxing Hosp, Dept Breast & Thyroid Surg,Sch Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Coll Med, Shaoxing 312000, Zhejiang, Peoples R China;[3]Zhejiang Chinese Med Univ, Med Res Ctr, Zhoushan Hosp Tradit Chinese Med, Zhoushan 316000, Zhejiang, Peoples R China;[4]Zhejiang Chinese Med Univ, Gynecol Dept, Zhoushan Hosp Tradit Chinese Med, Zhoushan 316000, Zhejiang, Peoples R China;[5]Zhejiang Chinese Med Univ, Med Res Ctr, Zhoushan Hosp Tradit Chinese Med, 355 Xinqiao Rd, Zhoushan 316000, Zhejiang, Peoples R China;[6]Zhejiang Chinese Med Univ, Gynecol Dept, Zhoushan Hosp Tradit Chinese Med, 355 Xinqiao Rd, Zhoushan 316000, Zhejiang, Peoples R China

年份：2022

卷号：236

外文期刊名：PATHOLOGY RESEARCH AND PRACTICE

收录：SCI-EXPANDED(收录号：WOS:000813378200006)、、Scopus(收录号：2-s2.0-85131810307)、WOS

基金：Funding This work was supported by the Nature Science Foundation of Zhe-jiang Province (No. LY18H060013 to WQL) , Foundation of Zhejiang Province Medical Health (2015PYA012, 2016RCA029 to WQL) .

语种：英文

外文关键词：Anti-angiogenic factors; Angiogenesis; Breast cancer; Tumor metastasis; Hypoxia

外文摘要：Breast cancer is one of the most common cancers in women, which can metastasize to other organs and has a high mortality rate. Previous studies have shown that angiogenic factors can contribute to tumor growth, development, and metastasis by altering the tumor microenvironment (TME). These angiogenic factors include a wide range of molecules, and in contrast, anti-angiogenic factors also inhibit angiogenesis and inhibit tumor growth. Evidence suggests that an imbalance between angiogenic and anti-angiogenic factors leads to angiogenesis, facilitating the migration of tumor cells from the source tissue in the breast to other organs such as the lung, liver, bone, and brain. By supplying blood through these neomicrovascular vessels, the nutrients and oxygen needed to grow tumor cells are provided. Due to the significant anti-tumor role of anti-angiogenesis factors, cancer researchers have always considered these molecules, and it is believed that anti-angiogenesis factors can be employed in cancer treatment approaches. This review discusses the role of anti-angiogenesis agents in breast cancer pathogenesis and reviews therapeutic approaches based on anti-angiogenesis factors.