文献类型：期刊文献

英文题名：A Pd-Catalyzed Cascade Protocol towards 2-Alkyl-4-aryl-4H-benz[1,4]oxazin-3-ones from Aryl Amines and 2-(2-Halophenoxy)alkanoates

作者：Feng, Gaofeng[1];Yin, Fangling[2];Chen, Fengjiang[1];Song, Qingbao[2];Qi, Chenze[1]

机构：[1]Shaoxing Univ, Inst Appl Chem, Shaoxing 312050, Peoples R China;[2]Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310027, Peoples R China

年份：2012

期号：4

起止页码：601

外文期刊名：SYNLETT

收录：SCI-EXPANDED(收录号：WOS:000300711600024)、、WOS、CCR-EXPANDED(收录号：WOS:000300711600024)

基金：Financial support by the University of Shaoxing is acknowledged with thanks. We also thank Dr. Jinglong Wu at the Zhejiang University for helpful discussion.

语种：英文

外文关键词：cascade reaction; palladium catalysis; amination; 4H-benz[1,4]oxazin-3-ones; lactamization

外文摘要：A cascade process, consisting of Pd-catalyzed intermolecular amination and subsequent thermal intramolecular amidation, has been established for efficient one-pot synthesis of 4H-benz[1,4]oxazin-3-ones from anilines and 2-(2-halophenoxy)alkanoates. Use of Cs2CO3 as the base was found to be determinant for the process and alkyl groups attached to the a position of alkanoates are beneficial for achieving good yields. Various substrates were compatible to afford the desired products in good to excellent yields. It is an attractive process for synthesizing a library of 4H-benz[1,4]oxazin-3-ones.