文献类型：期刊文献

英文题名：Immunometabolism in the tumor microenvironment and its related research progress

作者：Zhang, Ziheng[1];Hu, Yajun[1];Chen, Yuefeng[1];Chen, Zhuoneng[1];Zhu, Yexin[1];Chen, Mingmin[1];Xia, Jichu[1];Sun, Yixuan[2];Xu, Wenfang[3]

机构：[1]Shaoxing Univ, Med Sch, Shaoxing, Peoples R China;[2]Hubei Univ Sci & Technol, Hubei Key Lab Diabet & Angiopathy, Xianning, Peoples R China;[3]Shaoxing Univ, Dept Clin Lab, affiliated Hosp, Shaoxing, Peoples R China

年份：2022

卷号：12

外文期刊名：FRONTIERS IN ONCOLOGY

收录：SCI-EXPANDED(收录号：WOS:000885596800001)、、Scopus(收录号：2-s2.0-85141934212)、WOS

基金：Funding This work was supported by the Medical and Health Project Zhejiang Provincial Department of Health (2023KY1273) in the collection, analysis, and in the decision to submit the article for publication.

语种：英文

外文关键词：tumor microenvironment; glucose metabolism; lipid metabolism; Tregs; macrophages; NK cells

外文摘要：The tumor immune microenvironment has been a research hot spot in recent years. The cytokines and metabolites in the microenvironment can promote the occurrence and development of tumor in various ways and help tumor cells get rid of the surveillance of the immune system and complete immune escape. Many studies have shown that the existence of tumor microenvironment is an important reason for the failure of immunotherapy. The impact of the tumor microenvironment on tumor is a systematic study. The current research on this aspect may be only the tip of the iceberg, and a relative lack of integrity, may be related to the heterogeneity of tumor. This review mainly discusses the current status of glucose metabolism and lipid metabolism in the tumor microenvironment, including the phenotype of glucose metabolism and lipid metabolism in the microenvironment; the effects of these metabolic methods and their metabolites on three important immune cells Impact: regulatory T cells (Tregs), tumor-associated macrophages (TAM), natural killer cells (NK cells); and the impact of metabolism in the targeted microenvironment on immunotherapy. At the end of this article,the potential relationship between Ferroptosis and the tumor microenvironment in recent years is also briefly described.