文献类型：期刊文献

英文题名：Synthesis of Multifunctional Mn₃O₄-Ag₂S Janus Nanoparticles for Enhanced T₁-Magnetic Resonance Imaging and Photo-Induced Tumor Therapy

作者：Lu, Yuguang[1];Wu, Yuling[1];Tang, Zhe[1];Hou, Yike[1];Cui, Mingyue[1];Huang, Shuqi[1];Long, Binghua[1];Yu, Zhangsen[2];Iqbal, Muhammad Zubair[1];Kong, Xiangdong[1]

机构：[1]Zhejiang Sci Tech Univ, Inst Smart Biomed Mat, Sch Mat Sci & Engn, Hangzhou 310018, Peoples R China;[2]Shaoxing Univ, Sch Med, Med Sci Res Ctr, Lab Nanomed, Shaoxing 312000, Peoples R China

年份：2023

卷号：23

期号：21

外文期刊名：SENSORS

收录：SCI-EXPANDED(收录号：WOS:001103318200001)、、EI(收录号：20234615067173)、Scopus(收录号：2-s2.0-85176884688)、WOS

基金：The authors acknowledge the Zhejiang International Science and Technology Cooperation Project (2021C01180, 2019C04020), and the Research Foundation of Zhejiang Sci-Tech University (18012134-Y), and Medical Science Research Center at Shaoxing University for providing material characterization and technical support that have contributed to the results reported in this paper.

语种：英文

外文关键词：ultra-small Janus nanoparticles; cancer theranostics; T-1 contrast agents; magnetic resonance imaging; photo-responsive materials

外文摘要：The global burden of cancer is increasing rapidly, and nanomedicine offers promising prospects for enhancing the life expectancy of cancer patients. Janus nanoparticles (JNPs) have garnered considerable attention due to their asymmetric geometry, enabling multifunctionality in drug delivery and theranostics. However, achieving precise control over the self-assembly of JNPs in solution at the nanoscale level poses significant challenges. Herein, a low-temperature reversed-phase microemulsion system was used to obtain homogenous Mn3O4-Ag2S JNPs, which showed significant potential in cancer theranostics. Structural characterization revealed that the Ag2S (5-10 nm) part was uniformly deposited on a specific surface of Mn3O4 to form a Mn3O4-Ag2S Janus morphology. Compared to the single-component Mn3O4 and Ag2S particles, the fabricated Mn3O4-Ag2S JNPs exhibited satisfactory biocompatibility and therapeutic performance. Novel diagnostic and therapeutic nanoplatforms can be guided using the magnetic component in JNPs, which is revealed as an excellent T1 contrast enhancement agent in magnetic resonance imaging (MRI) with multiple functions, such as photo-induced regulation of the tumor microenvironment via producing reactive oxygen species and second near-infrared region (NIR-II) photothermal excitation for in vitro tumor-killing effects. The prime antibacterial and promising theranostics results demonstrate the extensive potential of the designed photo-responsive Mn3O4-Ag2S JNPs for biomedical applications.