文献类型：期刊文献

英文题名：N-halamines functionalized PCL nanofibrous yarns with antimicrobial properties for sutures applications

作者：Wang, Yingfeng[1,2];Liao, Ziyi[1];Huang, Ming[1];Li, Kaizhun[1];Pan, Nengyu[2];Hou, Hao[1];Ma, Wei[3];Yin, Maoli[1]

机构：[1]Anhui Polytech Univ, Coll Text & Garments, Wuhu 241000, Anhui, Peoples R China;[2]Shaoxing Univ, Key Lab Clean Dyeing & Finishing Technol Zhejiang, Shaoxing 312000, Zhejiang, Peoples R China;[3]Changshu Inst Technol, Sch Text Clothing & Design, Suzhou 215500, Jiangsu, Peoples R China

年份：2025

卷号：339

外文期刊名：MATERIALS CHEMISTRY AND PHYSICS

收录：SCI-EXPANDED(收录号：WOS:001450766700001)、、EI(收录号：20251218069327)、Scopus(收录号：2-s2.0-105000153018)、WOS

基金：The authors would like to thank for the Opening Project of Key Laboratory of Clean Dyeing and Finishing Technology of Zhejiang Province (QJRZ2209) , the Natural Science Research Project of Colleges and Universities in Anhui Province (2022AH050966) , the Natural Science Foundation of Colleges in Jiangsu Province (No.23KJB430003) , and the research funding of Anhui Polytechnic University (Xjky2022073, Xjky2022069) .

语种：英文

外文关键词：N-halamine; Antimicrobial; Nanofiber; Polycaprolactone

外文摘要：Post-surgical site infections (PSSI) pose significant challenges in clinic treatment, and the antibacterial modification of medical materials is an effective strategy to combat these issues. In this work, a monomeric N-halamines (DCDMH) was doped in PCL matrix via electrospinning process, and further processed using a conventional twisting method to yield nanofiber-based yarns. The micro/nano-structure of the PCL-based electrospun nanofibrous yarns (ENYs) enables the effective release of N-halamines and exhibits suitable storage stability after 30 days. The N-halamine modified ENYs effectively inhibited 100 % of E. coli O157:H7, S. aureus, and C. albicans within 1 min, resulting impressive antimicrobial capacities. The effect of N-halamines dosage on the morphology and mechanical properties of fabricated ENYs was assessed. Furthermore, the in vitro degradation, hemocompatibility, and protein adsorption properties of the synthesized nanofibrous yarns were also evaluated. The prepared ENYs with good hemocompatibility and antimicrobial properties, suggesting a novel approach for the development of medical materials, specifically for surgical sutures materials.