文献类型：期刊文献

中文题名：幽门螺杆菌根除后胃黏膜的病理变迁

英文题名：Pathological changes of gastric mucosa after eradication of Helicobacter pylori

作者：葛建荣[1];董来华[1];陈龙根[2];张巧英[1];茅育蕾[3]

机构：[1]绍兴文理学院医学院附属医院病理科;[2]绍兴文理学院医学院附属医院消化内科;[3]绍兴文理学院医学院附属医院内镜室

年份：2005

卷号：20

期号：16

起止页码：911

中文期刊名：临床荟萃

外文期刊名：Clinical Focus

收录：北大核心2004、北大核心

语种：中文

中文关键词：螺杆菌,幽门;免疫化学;胃黏膜;萎缩;肠化;染剂和染色法

外文关键词：Helicobacter pylori;gastric mucosa; atrophy ; intestinal metaplasia;immunochemistry

中文摘要：目的探讨根除幽门螺杆菌(Hp)对胃黏膜萎缩、肠上皮化生等癌前病变的转归,以及胃黏膜上皮细胞增殖指标ki-67表达的影响。方法67例Hp感染且有胃黏膜萎缩和(或)肠上皮化生的慢性胃炎患者,随机分为实验组(37例)和对照组(30例),分别给予Hp根除和对症治疗,1年后复查,比较Hp根除与否对胃黏膜萎缩、肠上皮化生等癌前病变的影响;用免疫组化方法检测治疗前后胃黏膜上皮细胞增殖指标ki-67的表达,比较Hp根除与否对它的影响。结果实验组炎症程度减轻(34/37,91.9%,P<0.01),活动性炎症者减少(P<0.01),萎缩、肠上皮化生等癌前病变减轻或逆转(21/32,65.6%vs15/26,57.7%,均P<0.05);ki-67表达降低(46.5±27.7vs15.4±18.7,P<0.01)。结论根除Hp可使胃黏膜炎症程度减轻,活动性炎症消失,萎缩、肠化等癌前病变减轻或逆转,胃黏膜上皮细胞增殖指标ki-67表达减少,从而有利于预防胃癌的发生。

外文摘要：Objective To study the effect of Helicobacter pylori(Hp) eradication on the precancerous lesion of gastric mucosa such as atrophy and intestinal metaplasia,and on the expression of ki-67 protein.Methods Sixty-seven chronic gastritis patients with Hp infection and glandula atrophy and/or intestinal metaplasia in the gastric mucosa were randomly divided into two groups: experimental group of 37 cases and control group of 30 cases.The former was given anti-Hp medication,while the latter,non anti-Hp medication.An examination was repeated one year later to compare the effect of Hp eradication on precancerous lesions such as atrophy and intestinal metaplasia.Immunohistochemical stain was used to detect the expression of ki-67 before and after the treatment,and the relationship between Hp eradication and expression of ki-67 was also investigated.Results In the experimental group,the degree of chronic inflammation of gastric mucosa ameliorated (34/37,(91.9%),P<(0.01)).The number of active inflammation cases was reduced(P<(0.01)).Atrophy and intestinal metaplasia were ameliorated or reversed(21/32,(65.6%) vs 15/26,(57.7%),All P<(0.05)),and the expression of ki-67 was reduced,positive cell labeling index before and after the treatment (46.5)±(27.7) vs (15.5)±(18.7)(P<(0.01)).Conclusion Hp eradication may relieve chronic inflammation and precancerous lesions such as atrophy and intestinal metaplasia of gastric mucosa,stop active inflammation and reduce the expression of ki-67.It may help to prevent gastric carcinoma.