文献类型：期刊文献

英文题名：SERS Detection of Nucleobases in Single Silver Plasmonic Nanopores

作者：Cao, Jiao[1];Liu, Hai-Ling[1,2];Yang, Jin-Mei[1];Li, Zhong-Qiu[1];Yang, Dong-Rui[1];Ji, Li-Na[3];Wang, Kang[1];Xia, Xing-Hua[1]

机构：[1]Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China;[2]Shaoxing Univ, Dept Chem, Shaoxing 312000, Peoples R China;[3]Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China

年份：2020

卷号：5

期号：7

起止页码：2198

外文期刊名：ACS SENSORS

收录：SCI-EXPANDED(收录号：WOS:000573554900042)、、EI(收录号：20203809202913)、Scopus(收录号：2-s2.0-85088607274)、WOS

基金：The authors acknowledge support for this work from the National Natural Science Foundation of China (21874068, 21575059, and 21627806), State Key Laboratory of Analytical Chemistry for Life Science (5 431ZZXM1 90 7, SKLACLS1910), and National Key R&D Program of China (2017YFA07005).

语种：英文

外文关键词：silver; self-assembly; single plasmonic nanopore; SERS; nucleobase detection

外文摘要：Conventional ion current-based nanopore techniques that identify single molecules are hampered by limitations of providing only the ionic current information. Here, we introduce a silver nanotriangle-based nanopore (diameter < 50 nm) system for detecting molecule translocation using surface-enhanced Raman scattering. Rhodamine 6G is used as a model molecule to study the effect of an electric field (-1 V) on the mass transport. The four DNA bases also show significantly different SERS signals when they are transported into the plasmonic nanopore. The observations suggest that in the electric field, analyte molecules are driven into the nanopipette through the hot spot of the silver nanopore. The plasmonic nanopore shows great potential as a highly sensitive SERS platform for detecting molecule transport and paves the way for single molecule probing.