文献类型：期刊文献

英文题名：Navigating the role of protein lactylation in prostate cancer and its implications for immunotherapy

作者：Li, Dongzhang[1,2];Wang, Kaifeng[1,2];Lou, Guantao[1,2];Li, Wangjian[1,2];Ma, Quan[1,2];Liu, Yu'e[3,4];Chen, Yongliang[1,2]

机构：[1]Shaoxing Cent Hosp, Dept Urol, Shaoxing 312030, Zhejiang, Peoples R China;[2]Shaoxing Univ, Cent Affiliated Hosp, Dept Urol, Shaoxing 312030, Zhejiang, Peoples R China;[3]Harvard Med Sch, Boston Childrens Hosp, Dana Farber Canc Inst, Boston, MA 02115, USA;[4]Tongji Univ, Shanghai East Hosp, Sch Med, Dept Neurosurg, Shanghai 200120, Peoples R China

年份：2025

卷号：16

期号：8

起止页码：2706

外文期刊名：JOURNAL OF CANCER

收录：SCI-EXPANDED(收录号：WOS:001513721800021)、、Scopus(收录号：2-s2.0-105007968711)、WOS

基金：Acknowledgements This review is supported by Zhejiang Provincial Medical Health Technology Plan Project 2022KY1315 (Kaifeng Wang) and 2023KY1276 (Yongliang Chen) . All the figures were generated via BioRenders, https://BioRender.com .

语种：英文

外文关键词：lactylation; prostate cancer; immunotherapy; immune checkpoints; tumor microenvironment

外文摘要：Prostate cancer is an aggressive malignancy with high prevalence and significant mortality, characterized by its remarkable metabolic adaptability and immune complexity. Emerging evidence has highlighted the critical role of post-translational modifications (PTMs) in cancer biology, with protein lactylation gaining attention as a novel PTM with profound implications. Lactylation, derived from lactate, links the altered metabolic processes of tumor cells to diverse cellular functions, including epigenetic regulation and protein dynamics. It significantly influences tumor progression, immune evasion, and therapeutic resistance by modulating key immune cells within the tumor microenvironment. The immunosuppressive conditions created by lactate and lactylation favor tumor survival in prostate cancer. Thus, targeting lactylation offers innovative strategies for treating prostate cancer. By leveraging lactylation modulation, particularly in combination with immune checkpoint inhibitors, there is potential to enhance anti-tumor immune responses and improve treatment outcomes. This review explores the intersection of metabolic alterations and immune modulation, underscoring lactylation as a promising therapeutic avenue in prostate cancer.