文献类型：期刊文献

中文题名：碱性阴离子交换树脂催化酯交换反应制备 1-羟基-2-甲基-4-乙酰氧基-2-丁烯的研究

英文题名：Ester Exchange Reaction Catalyzed by Basic Anion-Exchanged Resins to Prepare 1-Hydroxy-2-methyl-4-acetyloxy-2-butene

作者：叶伟东[1];沈润溥[2];虞国棋[1];张伯引[1];王奎[1]

机构：[1]浙江医药股份有限公司新昌制药厂,浙江新昌312500;[2]绍兴文理学院化学化工学院,浙江绍兴312000

年份：2008

卷号：22

期号：2

起止页码：316

中文期刊名：高校化学工程学报

外文期刊名：Journal of Chemical Engineering of Chinese Universities

收录：CSTPCD、、EI(收录号：20082111272698)、北大核心2004、Scopus(收录号：2-s2.0-43749108358)、CSCD2011_2012、北大核心、CSCD

基金：绍兴市重点科研项目(2003109)

语种：中文

中文关键词：VA乙酸酯;1-羟基-2-甲基-4-乙酰氧基-2-丁烯;酯交换反应;碱性阴离子交换树脂;反应精馏

外文关键词：retinol acetate;1-hydroxy-2-methyl-4-acetyloxy-2-butene;ester exchange reaction;basic anion-exchanged resins;reaction-distillation

中文摘要：用碱性阴离子交换树脂催化1-甲酰氧基-2-甲基-4-乙酰氧基-2-丁烯进行酯交换反应制备1-羟基-2-甲基-4-乙酰氧基-2-丁烯,反应的选择性由85%提高到99.5%,并因采用反应精馏的方式将反应时间由12h缩短到5h,收率由77%提高到93%,后处理方便,具有重要的工业意义;这一改进对类似的反应也有重要意义。

外文摘要：A new process of ester exchange reaction for producing 1-hydroxy-2-methyl-4-acetyloxy-2-butene from 1-formyloxy-2-methyl-4-acetyloxy-2-butene was proposed.The basic anion-exchanged resin was used as catalyst instead of the conventionally used NaHCO3,and the reaction-distillation method was adopted to simplify the ester exchange process.The results show that the new process proposed can enhance the selectivity of the ester exchange reaction from 85% to 99.5%,shorten the reaction time from 12 h to 5 h,and increase the yield of the product from 77% to 93%.Moreover,the post-treatment of the ester exchange process proposed is more convenient.All these demonstrate that the proposed new process has great industrial value and referential significance for the synthesis of similar compounds via ester exchange reaction.