文献类型：期刊文献

英文题名：The combination of autologous mesenchymal stem cell-derived exosomes and neurotrophic factors as an intervention for amyotrophic lateral sclerosis

作者：Ding, Yingyin[1,2];Botchway, Benson O. A.[3];Zhang, Yon[1];Jin, Tian[1];Liu, Xuehong[1,4]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Hangzhou Normal Univ, Sch Basic Med Sci, Hangzhou, Zhejiang, Peoples R China;[3]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China;[4]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China

年份：2022

卷号：242

外文期刊名：ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

收录：SCI-EXPANDED(收录号：WOS:000798752300003)、、Scopus(收录号：2-s2.0-85125939425)、WOS

语种：英文

外文关键词：Mesenchymal stem cell; Exosomes; Neurotrophic factors; Amyotrophic lateral sclerosis

外文摘要：Amyotrophic lateral sclerosis is a chronic progressive degeneration of motor neurons and has a high mortality. Riluzole and edaravone are the only approved medications currently being used for amyotrophic lateral sclerosis in clinical settings. However, they can lead to serious complications, such as injuries to the liver and kidney. To date, there is no effective treatment for amyotrophic lateral sclerosis. In this regard, investigations concerning the employment of exosomes, mesenchymal stem cells, and neurotrophic factors to ameliorate amyotrophic lateral sclerosis are attracting considerable attention in the scientific commu-nity. Herein, we systematically analyze the relationship relevant to autologous mesenchymal stem cell derived-exosomes, neurotrophic factors and amyotrophic lateral sclerosis. Mesenchymal stem cells mod-ulate immune response, mitigate oxidative stress, promote neuronal regeneration, and differentiate into neuronal and glial cells. Furthermore, exosomes from mesenchymal stem cells exert beneficial effects on their mother cells by preventing abnormal differentiation of mesenchymal stem cells. Similarly, neuro-trophic factors regulate inflammatory response, stimulate the neuron repair, and the recovery of neuronal functioning. Therefore, autologous mesenchymal stem cells-derived exosomes combined with neurotrophic factors could potentially be an effective interventional medium for amyotrophic lateral sclerosis. (c) 2022 Published by Elsevier GmbH.