文献类型：期刊文献

英文题名：Antithrombin III is a Novel Predictor for Contrast Induced Nephropathy After Coronary Angiography

作者：Wu, Rui[1];Kong, Yiwei[1];Yin, Jianyong[1];Liang, Rulian[1];Lu, Zeyuan[1];Wang, Niansong[1];Zhao, Qing[2];Zhou, Yang[3];Yan, Chungen[4];Wang, Feng[1];Liang, Mingyu[5,6]

机构：[1]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Jiangsu Univ, Affiliated Shanghai Peoples Hosp 8,Dept Nephrol, 600 Yishan Rd, Shanghai 200233, Peoples R China;[2]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Cardiol, Shanghai, Peoples R China;[3]Harbin Med Univ, Affiliated Hosp 1, Dept Nephrol, Harbin, Heilongjiang, Peoples R China;[4]Shaoxing Univ, Sch Med, Dept Internal Med, Shaoxing, Peoples R China;[5]Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA;[6]Med Coll Wisconsin, Ctr Syst Mol Med, Milwaukee, WI 53226 USA

年份：2018

卷号：43

期号：1

起止页码：170

外文期刊名：KIDNEY & BLOOD PRESSURE RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000428819600018)、、Scopus(收录号：2-s2.0-85042196088)、WOS

基金：This work was sponsored by the National Natural Science Foundation of China (81570603 and 81770741), the Health and Family Planning Commission of Shanghai Xuhni District (SHXH201605) and Shanghai Pujiang Talent Projects (15PJ1406700). Thanks to Dr. Anna Williams of Medical College of Wisconsin for language editing.

语种：英文

外文关键词：Antithrombin III; Contrast induced nephropathy; Predictor; Coronary angiography

外文摘要：Background/Aims: Antithrombin III (AT III) is an important endogenous anticoagulant and has strong anti-inflammatory properties. Low AT III activity is considered to be a predictor of poor outcomes in several conditions, including acute kidney injury after cardiac surgery. However, the association between the AT III level and the occurrence of contrast induced nephropathy (CIN) has not been elucidated. In this study, our aim was to identify the potential predictive value of AT III for CIN. Methods: We enrolled a total of 460 patients who underwent coronary angiography (CAG) from January 2015 to December 2016 in coronary care units (CCU). AT III activity in plasma collected before CAG was measured and <75% was considered low activity according to reference values. A cross-sectional study on CIN after CAG was conducted and the risk factors were analyzed. CIN was diagnosed according to the KDIGO guideline. Results: Of these 460 patients undergoing CAG, 125 (27.17%) progressed to CIN. The incidence of CIN was significantly higher in patients with low AT III activity compared to patients with normal AT III activity (Pearson's chi-squared test P=0.002). As AT III activity declined, the prevalence of CIN progressively increased, with the highest value (58.8%) in patients with an AT III activity <60%. Moreover, the AT III activity was significantly lower in CIN patients than in non-CIN patients (84.43 +/- 16.3% vs. 92.14 +/- 13.94%, P<0.001). After multivariable analysis, AT III activity <75% remained a significant independent predictor of CIN (OR 2.207,95% CI [1.29-3.777]; P=0.004) as well as baseline serum creatinine (OR 1.009,95% CI [1.001-1.016]; P=0.026). Conclusions: Patients with low AT III activity had a higher risk of developing CIN after CAG. The initial AT. activity may be a novel independent predictor for CIN. (c) 2018 The Author(s) Published by S. Karger AG, Basel