文献类型：期刊文献

英文题名：H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

作者：Luo, Mengqiang[1,2]; Zhang, Yaohong[1]; Fang, Ping[1]; Li, Yan[1]; Qi, Chenze[1]; Li, Yong[1]; Shen, Runpu[2]; Cheng, Kai[1]; Wang, Hai[1]

机构：[1] School of Chemistry and Chemical Engineering, Shaoxing University, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, School of Life Science, Zhejiang, Shaoxing, 312000, China; [2] School of Chemistry and Chemical Engineering, Shaoxing University, Zhejiang Engineering Research Center of Fat-soluble Vitamin, Zhejiang, Shaoxing, 312000, China

年份：2022

卷号：20

期号：3

起止页码：630

外文期刊名：Organic and Biomolecular Chemistry

收录：EI(收录号：20220511555966)、Scopus(收录号：2-s2.0-85123618955)

语种：英文

外文关键词：Catalysts - Toxic materials

外文摘要：An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones. This journal is ? The Royal Society of Chemistry