文献类型：期刊文献

英文题名：Predictive value of the red blood cell distribution width-to-platelet ratio for hepatic fibrosis

作者：Ding Yuyun[1];Tao Zhihua[2];Wang Haijun[3];Liao Zhaoping[4];Zhu Xiaoli[5];Xu Wenfang[6];Jin Faxiang[6];Liu Hongmei[6]

机构：[1]Shaoxing Univ, Dept Lab Med, Affiliated Hosp, Shaoxing, Peoples R China;[2]Zhejiang Univ, Dept Lab Med, Affiliated Hosp 2, Sch Med,Lab Med, Hangzhou, Zhejiang, Peoples R China;[3]Zhejiang Univ, Dept Pathol, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China;[4]Zhejiang Univ, Dept Blood Transfus, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China;[5]Taizhou Hosp Zhejiang Prov, Dept Lab Med, Linhai City, Peoples R China;[6]Shaoxing Univ, Dept Lab Med, Affiliated Hosp, Shaoxing, Peoples R China

年份：2019

卷号：54

期号：1

起止页码：81

外文期刊名：SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

收录：SCI-EXPANDED(收录号：WOS:000462902700012)、、Scopus(收录号：2-s2.0-85060338549)、WOS

基金：This study was funded by the National Natural Science Foundation of China [Grant no. 81271917] and the National Natural Science Foundation of Zhejiang Province [LY16H160023].

语种：英文

外文关键词：RPR; hepatic fibrosis; noninvasive; WBC; RDW; PLT

外文摘要：Aims: The red blood cell distribution width-to-platelet ratio (RPR) has been reported to be an indicator of hepatic fibrosis in patients with chronic hepatitis B (HBV), nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C (HCV). However, no research has explored the RPR in all patients with hepatic fibrosis. There is a recognized need to establish whether the RPR could assess hepatic fibrosis and reflect the severity of fibrosis, regardless of the patient's etiology. Methods: Quantitative data from 1282 patients who underwent liver biopsy between January 2010 and December 2014 at the Second Affiliated Hospital of Zhejiang University School of Medicine were included. The etiologies included HBV or HCV infection, NAFLD, schistosomiasis, granulomatous liver disease, and vascular abnormalities. Five noninvasive models were calculated for all patients based on laboratory parameters. The degrees of fibrosis severity were evaluated based on the Metavir scoring scale. Results: The RPR demonstrated the best accuracy of predicting hepatic fibrosis among the selected five models (0.75, p < .001) regardless of etiology. In addition, the RPR values increased with advanced hepatic fibrosis progression. Furthermore, combining the RPR with the white blood cell (WBC) count improved the accuracy of grading hepatic fibrosis as reflected by the likelihood ratio (LR + 9.03, LR - 0.49). Conclusion: The RPR is a useful indicator for hepatic fibrosis, regardless of etiology, and can reflect the severity of fibrosis. This study supports further clinical development of the RPR both in a stepwise manner or in combination with inflammatory parameters to improve the accuracy of scoring hepatic fibrosis.