文献类型：期刊文献

英文题名：Meta-Analysis of Sleep Deprivation Effects on Patients With Depression

作者：Hu, Baiqi[1,2,3];Liu, Chunyan[4];Mou, Tingting[2];Luo, Fangyi[2];Lv, Tingting[2];Qian, Chao[1];Zhang, Jian[2];Ye, Mengfei[1];Liu, Zheng[2]

机构：[1]Med Coll Shaoxing Univ, Shaoxing Peoples Hosp 7, Affiliated Mental Hlth Ctr, Dept Psychiat, Shaoxing, Peoples R China;[2]Shaoxing Univ, Sci Res Ctr, Dept Behav Neurosci, Sch Med, Shaoxing, Peoples R China;[3]China Med Univ, Shaoxing Hosp, Dept Neurol, Shaoxing, Peoples R China;[4]Shaoxing Univ, Shaoxing Peoples Hosp, Affiliated Hosp 1, Dept Orthoped, Shaoxing, Peoples R China

年份：2021

卷号：12

外文期刊名：FRONTIERS IN PSYCHIATRY

收录：SSCI(收录号：WOS:000731832000001)、SCI-EXPANDED(收录号：WOS:000731832000001)、、Scopus(收录号：2-s2.0-85121359832)、WOS

基金：Funding This work was funded by the Public Welfare Technology Applied Research Projects in Zhejiang Province (no. 2016C33191) and the Zhejiang Medical Health Science and Technology Project (no. 2019KY724 and 2020KY332).

语种：英文

外文关键词：sleep deprivation (SD); depression; meta-analysis; patients; review

外文摘要：Objective: Depression is a common disorder with a high recurrence rate. Since the effect of sleep deprivation on depression in existing studies were inconsistent, the present study aimed to reassess the effects of SD on patients by performing a meta-analysis of updated research.
Methods: PubMed, Embase, the Cochrane Library, and Web of Science were searched for articles before January 20th, 2021. Data on participant characteristics, SD characteristics, adjunctive method and tests for depression were extracted. A comprehensive analysis was conducted to assess the effect of SD on depression and subgroup analysis was used to determine the sources of heterogeneity.
Results: In total, 8 articles were included. An SD time of < 7 days slightly worsened depression levels [0.24 (-0.21, 0.69); I-2 = 0%; P = 0.43], a time of 7-14 days had antidepressant effects [-1.52 (-2.07, -0.97); I-2 = 19.6%; P = 0.288], and a time of more than 14 days also worsened depression [0.76 (0.12, 1.40); I-2 = 43.7%; P = 0.169].
Conclusion: SD may serve as an effective antidepressant measure in humans when the time was 7-14 days, while a time of < 7 days and more than 14 days worsened depression.