文献类型：期刊文献

英文题名：High-efficiency production of core-sheath nanofiber membrane via co-axial electro-centrifugal spinning for controlled drug release

作者：Gu, Jincheng[1];Yagi, Shinichi[1];Meng, Jie[1];Dong, Yubing[2];Qian, Chen[2];Zhao, Defang[3];Kumar, Alesh[4];Xu, Ting[5];Lucchetti, Agnese[6];Xu, Huaizhong[1]

机构：[1]Kyoto Inst Technol, Dept Biobased Mat Sci, Sakyoku, Kyoto 6068585, Japan;[2]Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, Hangzhou 310018, Zhejiang, Peoples R China;[3]Shaoxing Univ, Coll Text Garment, Zhejiang Sub Ctr Natl Carbon Fiber Engn Technol Re, Shaoxing Sub Ctr Natl Engn Res Ctr Fiber based Com, Shaoxing 312000, Peoples R China;[4]Natl Inst Technol, Dept Phys, Kurukshetra 136119, India;[5]Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Stomatol, Hangzhou, Zhejiang, Peoples R China;[6]Rhein Westfal TH Aachen, Inst Textiltechn, Aachen, Germany

年份：2022

卷号：654

外文期刊名：JOURNAL OF MEMBRANE SCIENCE

收录：SCI-EXPANDED(收录号：WOS:000796302700005)、、EI(收录号：20221812066659)、Scopus(收录号：2-s2.0-85129329854)、WOS

语种：英文

外文关键词：Electro centrifugal spinning; Core-sheath nanofibers; Bio-based polymer; Controlled drug release

外文摘要：Core-sheath nanofibers are a premium material to be used in the field of controlled drug release, however, a mass-production of this kind of fibers by current spinning methods is until now limited due to the issues of nozzle clogging and high costs. In this context, a brand-new technology, named co-axial electro-centrifugal spinning (ECS), which combines the technologies of co-axial electrospinning and centrifugal spinning, was proposed to fabricate core-sheath nanofibers in large amounts. Compared with traditional co-axial electrospinning, the inhouse-built co-axial ECS well addressed the nozzle cleaning problem. By means of the co-axial ECS, different kinds of core-sheath nanofibers were successfully produced. Being already extensively-applied biodegradable polymers, poly(vinyl alcohol) (PVA) and poly(L-lactic acid) (PLLA) were chosen to manufacture PVA/PLLA core/ sheath nanofibers with different core-to-sheath ratios in ultra-high production rate. Also, Paclitaxel drug was loaded in the PVA core component and its release was efficiently controlled thanks to the thickness and crystallinity of the PLA sheath. The in vitro drug release mechanism studied here suggested that the drug can still release out without the existence of porous microchannels. This accessible and low-cost technology may definitely offer a new insight into the fabrication of core-sheath nanofibers, allowing more researchers to tailor functional fabrics.