文献类型：期刊文献

中文题名：抗磷脂抗体对急性脑梗死患者预后影响的分析

英文题名：Effects of anti-phospholipid antibodies on the prognosis of patients with acute cerebral infarction

作者：王志英[1];徐志松[1];孙光胜[1]

机构：[1]绍兴文理学院附属医院老年内科

年份：2015

卷号：23

期号：7

起止页码：502

中文期刊名：中国慢性病预防与控制

外文期刊名：Chinese Journal of Prevention and Control of Chronic Diseases

收录：CSTPCD

基金：绍兴市科学技术局项目(2012B70071)

语种：中文

中文关键词：抗磷脂抗体;抗心磷脂抗体;狼疮抗凝物抗体;急性脑梗死

外文关键词：Anti-phospholipid antibodies; Anti-cardiolipin antibodies; Lupus anticoagulant antibodies; Acute cerebral infarction

中文摘要：目的探讨抗磷脂抗体对急性脑梗死患者病情严重程度及预后的影响,为提高脑梗死的诊断、治疗和预后提供依据。方法选择2012年1月至2014年2月在我院老年内科住院的162例急性脑梗死患者(病例组)为研究对象,同时选取在本院体检中心同期健康体检者150例为正常对照组,测定两组人群抗心磷脂抗体(ACA)总抗体及Ig G、Ig M、Ig A,抗磷脂酰丝氨酸抗体(APS)以及抗-β2糖蛋白I抗体(Anti-β2GPI)总抗体及Ig G、Ig M、Ig A,狼疮抗凝物抗体(LA)浓度,以神经功能缺损评分值(NIHSS)为因变量,以ACA、LA、APS和Anti-β2GPI各抗体浓度为自变量进行logistic回归分析,研究入选的自变量对急性脑梗死患者预后影响。结果病例组各抗体浓度检测值均高于正常对照组,差异均有统计学意义(P<0.05)。抗ACA-Ig G、LA与NIHSS值明显相关。治疗后ACA组、LA组神经功能缺损评分[分别为(30±5)、(27±5)分]均明显高于正常组[(18±6)分],ACA组、LA组中重度患者数均明显高于正常组,ACA组、LA组总有效率(分别为60.0%、59.1%)明显低于正常组(81.6%),差异均有统计学意义(P<0.05)。结论抗磷脂抗体与脑梗死密切相关,尤其ACA、LA。检测脑梗死患者ACA、LA对脑梗死的诊断、治疗和预后均具有重要意义。

外文摘要：Objective To explore the effects of anti-phospholipid antibodies on the severity and prognosis of the patients with acute cerebral infarction and to provide the base for improving diagnosis, treatment or prognosis of acute cerebral infarction. Methods During January of 2012 to February of 2014, 162 inpatients with acute cerebral infarction in the Department of Gerontological Internal Medicine of Affiliated Hospital served as the study subjects, and 150 healthy residents served as controls. The levels of anti-cardiolipin antibody （ACA） total antibody, IgG, IgM, IgA, anti-phosphatidylserine antibody （APS）, anti-β2 glyeoprotein I antibody （Anti-β2GPI） total antibody and IgG, IgM, IgA and Lupus anticoagulant antibodies （LA） in blood were measured for study subjects and controls. The Neurological Deficit Score （NIHSS） served as the dependent variable. ACA, LA, APS and Anti- β2GP served as the independent variables. Multivariate logistic regression analysis was used to study the influence of independent variables on prognosis of patients with acute cerebral infarction. Results The levels of all antibodies in study group was significantly higher than those in control group （P〈0.05）. The levels of anti ACA-IgG and LA were significantly associated with NIHSS scores. After treatment, the neurological deficit scores （30±5 and 27±5 ） of ACA and LA groups were significantly higher than that （18±6） of normal group. The numbers of severe patients in ACA group and LA group were significantly higher than that in normal group. The total efficient rates （60.0% and 59.1%） of ACA group and LA group were significantly lower than that （81.6%） of normal group （P〈0.05）. Conclusion Anti-phospholipid antibody is closely related with the prognosis of cerebral infarction, especially ACA and LA. ACA and LA levels should be detected in cerebral infarction patients, which are important significance for the diagnosis, treatment and prognosis of patients with cerebral infarction.