文献类型：期刊文献

英文题名：Curcumin Can Improve Spinal Cord Injury by Inhibiting TGF--SOX9 Signaling Pathway

作者：Yuan, Jiaying[1];Botchway, Benson O. A.[2];Zhang, Yong[1];Tan, Xiaoning[2];Wang, Xizhi[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Coll Med, Dept Histol & Embryol, Shaoxing, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Zhejiang, Peoples R China

年份：2019

卷号：39

期号：5

起止页码：569

外文期刊名：CELLULAR AND MOLECULAR NEUROBIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000469033100001)、、Scopus(收录号：2-s2.0-85064176599)、WOS

基金：This work was supported by the Natural Science Foundation of Zhejiang Province (No. LY19H170001) and Public Technology Applied Research Projects Foundation of Shaoxing City (No. 2017B70066).

语种：英文

外文关键词：Curcumin; SOX9 signaling pathway; NF-B signaling pathway; Spinal cord injury; Neuroregeneration; Anti-oxidation; Anti-inflammation

外文摘要：Spinal cord injury (SCI) is a severe nervous system disease with high morbidity and disability rate. Signaling pathways play a key role in the neuronal restorative mechanism following SCI. SRY-related high mobility group (HMG)-box gene 9 (SOX9) affects glial scar formation via Transforming growth factor beta (TGF-) signaling pathway. Activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) is transferred into nucleus to upregulate TGF--SOX9. Curcumin exhibits potent anti-inflammatory and anti-oxidant properties. Curcumin can play an important role in SCI recovery by inhibiting the expression of NF-B and TGF--SOX9. Herein, we review the potential mechanism of curcumin-inhibiting SOX9 signaling pathway in SCI treatment. The inhibition of NF-B and SOX9 signaling pathway by curcumin has the potentiality of serving as neuronal regenerative mechanism following SCI.