文献类型：期刊文献

英文题名：Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway

作者：Fan, Ruihua[1,2];Wang, Lvxia[1,2];Botchway, Benson O. A.[3];Zhang, Yong[2];Liu, Xuehong[1,2]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Peoples R China;[2]Shaoxing Univ, Sch Life Sci, Shaoxing, Peoples R China;[3]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China

年份：2022

卷号：15

外文期刊名：FRONTIERS IN MOLECULAR NEUROSCIENCE

收录：SCI-EXPANDED(收录号：WOS:000862453300001)、、Scopus(收录号：2-s2.0-85139231360)、WOS

基金：Funding This work was supported by the Natural Science Foundation of Zhejiang Province (no. LY19H170001).

语种：英文

外文关键词：spinal cord injury; ethyl pyruvate; high mobility group box-1 (HMGB1); toll-like receptors (TLRs); nuclear factor-kappa B (NF-kappa B); astrocytic activation

外文摘要：Spinal cord injury (SCI) is a high incident rate of central nervous system disease that usually causes paralysis below the injured level. The occurrence of chronic inflammation with the axonal regeneration difficulties are the underlying barriers for the recovery of SCI patients. Current studies have paid attention to controlling the instigative and developmental process of neuro-inflammation. Ethyl pyruvate, as a derivative of pyruvate, has strong anti-inflammatory and neuroprotective functions. Herein, we reviewed the recent studies of ethyl pyruvate and high mobility group box-1 (HMGB1). We think HMGB1 that is one of the main nuclear protein mediators to cause an inflammatory response. This protein induces astrocytic activation, and promotes glial scar formation. Interestingly, ethyl pyruvate has potent inhibitory effects on HMGB1 protein, as it inhibits chronic inflammatory response by modulating the HMGB1/TLR4/NF-kappa B signaling pathway. This paper discusses the potential mechanism of ethyl pyruvate in inhibiting chronic inflammation after SCI. Ethyl pyruvate can be a prospective therapeutic agent for SCI.