文献类型：期刊文献

英文题名：Levosimendan: A New Therapeutical Strategy in Patients with Renal Insufficiency

作者：Liu, Xinwen[1];Lu, Mengkai[1];Yu, Yanna[1];Shen, Nannan[1];Xia, Haijiang[2];Shi, Jiana[3];Fu, Yongping[2];Hu, Ying[3]

机构：[1]Shaoxing Univ, Affiliated Hosp, Dept Pharm, Shaoxing 312000, Peoples R China;[2]Shaoxing Univ, Affiliated Hosp, Dept Cardiovasc Med, Shaoxing 312000, Peoples R China;[3]Hangzhou Med Coll, Clin Pharm Ctr, Dept Pharm, Zhejiang Prov Peoples Hosp,Affiliated Peoples Hosp, Hangzhou, Peoples R China

年份：2024

外文期刊名：CARDIOVASCULAR DRUGS AND THERAPY

收录：SCI-EXPANDED(收录号：WOS:001285906400001)、、Scopus(收录号：2-s2.0-85200697538)、WOS

基金：The authors gratefully acknowledge the financial support provided by National Natural Science Foundation of China, Youth Science Foundation Project (No. 72204073), Zhejiang Medical and Health Science and Technology (No. 2023KY491), the Science and Technology Projects in the Zhejiang Province Department of Education (No. Y202146979, Y202249053), Shaoxing Health Science and Technology Plan Project (No. KY2022066), and Zhejiang Medical Association Clinical Medicine Project (2023ZYC-A55, 2022ZYC-Z37), the Ministry of Education Industry-University Cooperative Education Project (No. 22087043124451).

语种：英文

外文关键词：Levosimendan; Kidney; Heart failure; Cardiac surgery

外文摘要：Levosimendan, a Ca2 + sensitizer with positive inotropic effects, is primarily employed for the short-term treatment of acute decompensated heart failure (ADHF). Levosimendan exerts renal function protection through various mechanisms, including anti-apoptosis, anti-inflammatory, and antioxidant effects in vivo. Additionally, levosimendan may have a protective effect on individuals with heart failure and renal insufficiency, as well as on renal function impairment after cardiac surgery. However, the application of levosimendan in patients with severe renal dysfunction remains controversial. This article delves into the use of levosimendan in severe renal insufficiency, explores its impact on renal function, and provides a comprehensive overview of its impact on renal function after cardiac surgery.