文献类型：期刊文献

英文题名：Feasibility of Absent in Melanoma 2 as a Serological Marker in Relation to Complicated Community-Acquired Pneumonia in Children: A Prospective Cohort Study

作者：Hu, Linjie[1];Zhou, Peng[1];Wang, Shanlin[2];Shen, Yaping[1];Xing, Suli[1];Zhang, Yuehan[1];Zhu, Yanyan[2]

机构：[1]Shaoxing Univ, Zhejiang Univ, Shengzhou Peoples Hosp,Shengzhou Hosp,Sch Med, Shengzhou Branch,Dept Pediat,Affiliated Hosp 1, Shengzhou 312400, Zhejiang, Peoples R China;[2]Hangzhou Childrens Hosp, Dept Pediat, 195 Wenhui Rd, Hangzhou 310014, Zhejiang, Peoples R China

年份：2025

卷号：18

起止页码：5155

外文期刊名：INTERNATIONAL JOURNAL OF GENERAL MEDICINE

收录：SCI-EXPANDED(收录号：WOS:001567224000001)、、WOS

基金：This study was financially supported by Zhejiang Provincial Medical and Health Science and Technology Plan (No. 2023RC248) .

语种：英文

外文关键词：community-acquired pneumonia; children; absent in melanoma 2; outcomes; severity; biomarkers

外文摘要：Objective: Absent in melanoma 2 (AIM2) is associated with inflammation. We intended to determine whether serum AIM2 levels are related to severity and complications of community-acquired pneumonia (CAP) in children. Methods: In this prospective cohort study, serum AIM2 levels were measured in 305 children with CAP and in 100 healthy controls at the Hangzhou Children's Hospital between January 2022 and June 2023. CAP severity was assessed using the pediatric critical illness score (PCIS) and clinical pulmonary infection score (CPIS). In-hospital complicated CAP was identified as the outcome variable. Univariate and multivariate analyses were sequentially performed to determine the correlation between severity, outcome and serum AIM2 levels. Results: Children with CAP had higher serum AIM2 levels than controls (median, 1.45 ng/mL versus 0.36 ng/mL; P<0.001). Serum AIM2 levels in diseased children were independently correlated with PCIS (beta=-0.020; P=0.001) and CPIS (beta=0.092; P=0.002), were linearly related to likelihood of complicated CAP (P for nonlinear =0.057), and were independently associated with complicated CAP (odds ratio= 6.162; P=0.005). The outcome association was robust by calculating the E-value at 11.8 and was not moderated by age, sex, weight and more (all P interaction >0.05). Serum AIM2 levels and two independent predictors, PCIS and CPIS, were integrated to construct the model. The model was pictorially represented by the nomogram and exhibited satisfactory discrimination capability, validity, and stability under the receiver operating characteristic (ROC) curve, decision curve, and calibration curve. By computing the net reclassification improvement and integrated discrimination improvement indices and comparing the area under the ROC curve, the model significantly outperformed the combination of the PCIS and CPIS. Conclusion: Markedly enhanced serum AIM2 levels following CAP in children are highly linked to severity and complicated CAP, substantializing serum AIM2 as a biochemical metric for assessing the severity and identifying adverse outcomes of childhood CAP.