文献类型：期刊文献

英文题名：Production of functional spherical particles with porous hollow structures in water via oiling-out directional agglomeration

作者：Liu, Yanbo[1,2];Li, Maolin[1,2];Lin, Jiawei[1,2];Wei, Xuemei[4];Yu, Guoqi[4];Li, Kangli[1,3];Shen, Runpu[4];Chen, Mingyang[1,2,3];Zhou, Ling[1];Gong, Junbo[1,2,3]

机构：[1]Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China;[2]Haihe Lab Sustainable Chem Transformat, Tianjin 300192, Peoples R China;[3]Tianjin Univ, Zhejiang Inst, Shaoxing 312300, Zhejiang, Peoples R China;[4]Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Shaoxing 312000, Zhejiang, Peoples R China

年份：2023

卷号：25

期号：22

起止页码：9126

外文期刊名：GREEN CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001063048300001)、、EI(收录号：20233914782685)、Scopus(收录号：2-s2.0-85171894413)、WOS

基金：This work was financially supported by the Natural Science Foundation of Tianjin 21JCQNJC00580, the Key R & D Program of Zhejiang 2022C01208, the Opening Project of Zhejiang Engineering Research Center of Fat-soluble Vitamin (202204) and the Key Research and Development Project of Hebei 22372601D.

语种：英文

外文摘要：Porous hollow spherical particles benefit from special structural features and fascinating physicochemical properties resulting in widespread application. Particularly in pharmaceutical engineering, they have significant advantages for direct compression and drug combination. However, their large-scale application is severely hindered by the limitations of traditional production methods in terms of the use of complex equipment, high energy consumption and high organic solvent usage. In this work, we have developed an oiling-out directional agglomeration method to produce porous hollow indomethacin spherical particles by a simple heating-quenching-drying operation without the use of organic solvents and templating agents. Compared to commercial flake crystals, the indomethacin spherical products have higher average tensile strength (471% increase) and higher plastic deformability, i.e. better tabletability and compressibility. More importantly, nifedipine is successfully loaded into porous hollow indomethacin spherical particles based on molecular polarity differences. The composite particles with a core-shell structure exhibit excellent powder properties, tableting and anti-degradation performance, while also achieving sequential release of drugs. This contribution provides the basis for the development of drug formulation strategies and the design of functional crystalline materials.