文献类型：期刊文献

英文题名：Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury

作者：Zhou, Jingying[1];Huo, Xue[2];Botchway, Benson O. A.[2];Xu, Luyao[1];Meng, Xiaofang[1];Zhang, Songou[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Zhejiang, Peoples R China

年份：2018

卷号：2018

外文期刊名：NEURAL PLASTICITY

收录：SCI-EXPANDED(收录号：WOS:000429681700001)、、Scopus(收录号：2-s2.0-85050178764)、WOS

基金：This work was supported by the Natural Science Foundation of Zhejiang Province (no. LY15H170001) and the Public Technology Applied Research Project Foundation of Shaoxing City (no. 2015B70040).

语种：英文

外文摘要：Spinal cord injury (SCI) causes a high rate of morbidity and disability. The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/ chronic phases at different times. Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. The inhibition of the mTOR pathway by resveratrol has the potential of serving as a neuronal restorative mechanism following SCI.