文献类型：期刊文献

英文题名：The Inhibition of Inflammatory Signaling Pathway by Secretory Leukocyte Protease Inhibitor can Improve Spinal Cord Injury

作者：Tang, Renzhe[1];Botchway, Benson O. A.[2];Meng, Yanfeng[3];Zhang, Yong[1];Zhou, Conghui[1];Jiang, Junsong[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China;[3]Shaoxing Univ, Affiliated Hosp, Dept Orthoped, Shaoxing, Peoples R China

年份：2020

卷号：40

期号：7

起止页码：1067

外文期刊名：CELLULAR AND MOLECULAR NEUROBIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000515630400001)、、Scopus(收录号：2-s2.0-85078437439)、WOS

基金：This study was funded by the Natural Science Foundation of Zhejiang Province (Grant No. LY19H170001).

语种：英文

外文关键词：Ecretory leukocyte protease inhibitor; Spinal cord injury; Nuclear factor kappa beta signaling pathway; Inflammation; Oxidative stress

外文摘要：Spinal cord injury leads to loss of sensory motor functions below the damaged area, and can significantly affects physical and mental health. An effective spinal cord injury treatment is currently unavailable, in part, because of the intricacy of the brain, as well as the complex pathophysiological mechanism of the injury. Inflammation is an important biological process in multitudinous diseases, with no exception for spinal cord injury. Nuclear factor kappa beta (NF-kappa B) signaling pathway is a key inflammatory element, as it is involved in cell survival, apoptosis, proliferation, differentiation, and immune response. Activation of the NF-kappa B signaling pathway leads to the release of a large number of inflammatory factors that can affect tissue repair. Hence, the inhibition of inflammatory responses could improve the repair of injured spinal cord tissues. Secretory leukocyte protease inhibitor (SLPI) has anti-inflammatory and anti-bacterial properties, and promotes wound healing. SLPI can bind to the promoter region of tumor necrosis factor-alpha and interleukin-8 (IL-8) to inhibit the NF-kappa B signaling pathway. Additionally, SLPI can reduce secondary damages after spinal cord injury, and prevent further complications. In this report, we analyze the pathophysiological mechanism of spinal cord injury, the role of NF-kappa B signaling pathway following spinal cord injury, and how SLPI regulates the NF-kappa B signaling pathway to curtail inflammatory reaction.