文献类型：期刊文献

英文题名：Cerium Ammonium Nitrate (CAN)-Promoted C(sp²)-N Coupling of Secondary Amides with Aryl Boronic Acids: Entries to Tertiary Aryl Amides

作者：Feng, Gaofeng[1,2];Zhang, Chao[1];He, Jing-Yao[1];Cai, Tao[1];Xu, Wenzhe[1];Jin, Jian[3]

机构：[1]Shaoxing Univ, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Peoples R China;[2]Shaoxing Univ, Shangyu Coll, Shaoxing 312300, Peoples R China;[3]Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Chem Biol, Shanghai 200032, Peoples R China

年份：2025

外文期刊名：ORGANIC LETTERS

收录：SCI-EXPANDED(收录号：WOS:001457696000001)、、WOS

基金：We are grateful for the financial support by National Natural Science Foundation of China (Grant Nos. 21676166, 21302130 and 22478247).

语种：英文

外文摘要：A cerium ammonium nitrate (CAN)-promoted C(sp2)-N coupling reaction of secondary amides with aryl boronic acids has been realized, providing a new entry for the construction of structurally diverse tertiary aryl amides, which are widely found in various biologically active molecules. Preliminary mechanistic studies indicated that a radical pathway may be involved in the C(sp2)-N coupling process. Compared with other metal-catalyzed methods, which in some cases require well-designed catalysts, preassembled directing groups, and/or complicated operations, this methodology features a ligand- and directing group-free process, as well as ease of handling.