文献类型：期刊文献

英文题名：Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage

作者：Xia, Jiajie[1,2];Gao, Xinjie[3,4];Yao, Jun[5];Fei, Yuchao[3,4];Song, Dagang[2];Gu, Zhiwei[2];Zheng, Gang[2];Gu, Yuxiang[1,3,4];Tu, Chuanjian[6]

机构：[1]Fujian Med Univ, Affiliated Hosp 1, Neurosurg Res Inst, Dept Neurosurg, Fuzhou 350005, Fujian, Peoples R China;[2]Shaoxing Univ, Shaoxing Cent Hosp, Cent Affiliated Hosp, Dept Neurosurg, Shaoxing 312030, Zhejiang, Peoples R China;[3]Fudan Univ, Huashan Hospital, MOE Frontiers Ctr Brain Sci, Dept Neurosurg,State Key Lab Med Neurobiol, Shanghai, Peoples R China;[4]Fudan Univ, Inst Brain Sci, Shanghai 200000, Peoples R China;[5]Shaoxing Univ, Shaoxing Cent Hosp, Cent Affiliated Hosp, Dept Orthoped Surg, Shaoxing 312030, Zhejiang, Peoples R China;[6]China Med Univ, Shaoxing Cent Hosp, Dept Neurosurg, Shaoxing 312030, Zhejiang, Peoples R China

年份：2025

卷号：29

外文期刊名：BIOMATERIALS RESEARCH

收录：SCI-EXPANDED(收录号：WOS:001471633700001)、、WOS

基金：This study was funded by the Zhejiang Natural Science Fund (LBY24H180012), Tibet Natural Science Fund (XZ2020ZRZY37[Z]), Zhejiang Health and Pharmaceutical Science and Technology Plan (2023XY058), Zhejiang Medical Association Clinical Research Fund Project (2022ZYC-A74, 2023ZYC-Z22), Science and technology project of Zhejiang Association of Rehabilitation Medicine (ZKKY2024007), and Shaoxing Health and Wellness Plan (2022KY081).

语种：英文

外文摘要：Neural repair within the lesion cavity caused by intracerebral hemorrhage (ICH) remains a major therapeutic challenge. Hydrogels hold great potential in regenerative medicine as functional scaffolds. However, inadequate host cell infiltration and suboptimal delivery methods have limited their application in tissue engineering. Here, we describe an optimized decellularization approach to create injectable brain extracellular matrix (ECM) hydrogels for the treatment of ICH. The hydrogel exhibits excellent biodegradability and biocompatibility. In an ICH rat model, the hydrogel implanted into the stroke cavity promoted neural recovery, facilitated cell recruitment, enhanced angiogenesis, and inhibited inflammation in the peri-cavity region at 14 d post-implantation. Furthermore, the hydrogel improved cell proliferation and migration, reversed cell apoptosis, and modulated transcriptomic changes in vitro. Notably, the hydrogel may promote neuronal migration and neural functional recovery after ICH through the slit guidance ligand 2-receptor roundabout guidance receptor 1 (Slit2-Robo1) signaling pathway. These findings highlight the potential of brain ECM hydrogels as a promising strategy for brain tissue regeneration.