文献类型：期刊文献

英文题名：Polypyrrole-based nanotheranostic agent for MRI guided photothermal-chemodynamic synergistic cancer therapy

作者：Zhou, Bangyi[1];Yin, Chenhui[1];Feng, Qiang[1];Wu, Yiting[1];Pan, Xiaoyu[1];Liu, Chuang[2];Tian, Jinjin[1];Geng, Siqi[3];Wang, Kexin[1];Xing, Jie[2];Cao, Yi[2];Shou, Pingbo[1];Yu, Zhangsen[1];Wu, Aiguo[2]

机构：[1]Shaoxing Univ, Med Sci Res Ctr, Sch Med, Lab Nanomed, Shaoxing City 312000, Zhejiang, Peoples R China;[2]Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn,CAS Key Lab Magnet, Ningbo 315201, Zhejiang, Peoples R China;[3]Shaoxing Univ, Coll Life Sci, Shaoxing City 312000, Zhejiang, Peoples R China

年份：2021

卷号：13

期号：45

起止页码：19085

外文期刊名：NANOSCALE

收录：SCI-EXPANDED(收录号：WOS:000717072700001)、、EI(收录号：20214911272668)、Scopus(收录号：2-s2.0-85120373732)、WOS

基金：This work was financially supported by the project of Zhejiang Provincial Natural Science Foundation (LGF21H180005), Science and Technology Plan in Shaoxing City (2018C10011), College Students' Science and Technology Innovation Project of Zhejiang Province (2020R444018), National College Students Innovation and Entrepreneurship Training Program, China (201910349039X, 202010349004, 202010349051X). Medical and Health Science and Technology Plan Project of Zhejiang Province (2021KY1159). Medical and Health Science and Technology Plan Project of Shaoxing (2020A13024, 2020A13060).

语种：英文

外文关键词：Biocompatibility - Diseases - Infrared devices - Magnetic resonance - Mammals - Nanoparticles - Nanoprobes - Peptides - Polypyrroles - Redox reactions - Sulfur compounds - Tumors

外文摘要：Polypyrrole (PPy) nanoparticles have been widely studied in tumor photothermal therapy (PTT) for their significant photostability, good biocompatibility, and excellent photothermal performance. Herein, we report bovine serum albumin (BSA) stabilized PPy that were mineralized by MnO2 nanozyme on the surface (PPy@BSA-MnO2) to achieve synergistic photothermal and chemodynamic therapy (CDT) for breast cancer. In this multifunctional nanoplatform, the surface-loaded MnO2 undergoes a redox reaction with glutathione (GSH) to generate glutathione disulfide (GSSG) and Mn2+. Then, Mn2+ can convert H2O2 into a highly cytotoxic OH to achieve chemodynamic therapy (CDT) and possess good magnetic resonance (MR) T-1-weighted imaging capabilities to realize contrast imaging of the 4T1 tumor-bearing mouse models. In addition, PPy nanoparticles can efficiently convert near-infrared light energy into heat and achieve PTT. Most importantly, PPy@BSA-MnO2 nanoprobes have excellent in vitro 4T1 cell-killing effect and in vivo tumor-suppressive properties. The acute toxicity assessment results indicate that PPy@BSA-MnO2 nanoprobes have good biological safety. Therefore, the as-prepared multifunctional PPy@BSA-MnO2 nanoprobes possess excellent performance to promote MRI-guided PTT/CDT synergistic therapy for breast cancer treatment and have extensive clinical transformation and application prospects.