文献类型：期刊文献

英文题名：First characterization of three cyclophilin family proteins in the oyster, Crassostrea ariakensis Gould

作者：Xu, Ting[1,2];Xie, Jiasong[1];Yang, Shoubao[2];Ye, Shigen[1];Luo, Ming[1];Wu, Xinzhong[1,3]

机构：[1]Zhejiang Univ, Coll Anim Sci, Lab Marine Life Sci & Technol, Hangzhou, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Life Sci, Shaoxing, Zhejiang, Peoples R China;[3]Qinzhou Univ, Ocean Coll, Qinzhou City, Guangxi, Peoples R China

年份：2016

卷号：55

起止页码：257

外文期刊名：FISH & SHELLFISH IMMUNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000381537000026)、、WOS

语种：英文

外文关键词：Crassostrea ariakensis; Rickettsia-like organism; Cyclophilin; Ca-CyPs; Immune response

外文摘要：Cyclophilins (CyPs) are a family of proteins that bind the immunosuppressive agent cyclosporin A (CsA) with high-affinity and belong to one of the three superfamilies of peptidyl-prolyl cis-trans isomerases (PPlase). In this report, three cyclophilin genes (Ca-CyPs), including Ca-CyPA, Ca-CyPB and Ca-PPIL3, were identified from oyster, Crassostrea ariakensis Gould in which Ca-CyPA encodes a protein with 165 amino acid sequences, Ca-CyPB encodes a protein with 217 amino acid sequences and Ca-PPIL3 encodes a protein with 162 amino acid sequences. All of the three Ca-CyPs genes contain a typical CyP-PPIase domain with its signature sequences and Ca-CyPB contains an N-signal peptide sequences. Tissue distribution study revealed that Ca-CyPs were ubiquitously expressed in all examined tissues and the highest levels were observed in hemocytes. RLO incubation upregulated the mRNA expression levels of Ca-CyPs, indicating that three Ca-CyPs might be involved in oyster immune response against RLO infection. (C) 2016 Elsevier Ltd. All rights reserved.