文献类型：期刊文献

英文题名：Resveratrol can improve spinal cord injury by activating Nrf2/HO-1 signaling pathway

作者：Tang, Shi[1];Botchway, Benson O. A.[2];Zhang, Yong[1];Wang, Xichen[1];Huang, Min[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing 312000, Zhejiang Provin, Peoples R China;[2]Bupa Cromwell Hosp, London, England

年份：2024

卷号：251

外文期刊名：ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

收录：SCI-EXPANDED(收录号：WOS:001108105600001)、、Scopus(收录号：2-s2.0-85174848371)、WOS

基金：The Natural Science Foundation of Zhejiang Province supported this work (no. LY19H170001) .

语种：英文

外文关键词：Resveratrol; oxidative stress; spinal cord injury; Nrf2/HO-1 signal pathway; antioxidant; inflammatory response; reactive oxygen species

外文摘要：Spinal cord injury (SCI) often induces severe sensory and motor dysfunction. Oxidative stress is an important pathophysiological process of secondary SCI, and its inhibition could facilitate the alleviation of the injury. Resveratrol is a natural plant polyphenol compound that has significant antioxidant and anti-inflammatory effects. It can inhibit oxidative stress by activating the Nrf2/HO-1 signal pathway. In this report, we analyze the antioxidant effect of resveratrol in SCI, clarify the specific mechanism of action and provide a theoretical basis for the clinical employment of resveratrol for SCI.