文献类型：期刊文献

英文题名：Dark chocolate intake and cardiovascular diseases: a Mendelian randomization study

作者：Yang, Juntao[1];Zhou, Jiedong[2];Yang, Jie[2];Lou, Haifei[1];Zhao, Bingjie[2];Chi, Jufang[3];Tang, Weiliang[1]

机构：[1]Shaoxing Peoples Hosp, Dept Cardiol, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Shaoxing 312000, Zhejiang, Peoples R China;[3]Zhuji Peoples Hosp, Dept Cardiol, Zhuji 311800, Zhejiang, Peoples R China

年份：2024

卷号：14

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：SCI-EXPANDED(收录号：WOS:001148349200019)、、Scopus(收录号：2-s2.0-85181907706)、WOS

基金：This study was funded by Provincial innovative talents training object (60001383), Special Project of Science and Technology Plan of Shaoxing City, China (2020B33001) and Zhejiang Traditional Chinese Medicine Science and Technology Program (2023ZL184).

语种：英文

外文摘要：Previous intervention studies have shown some benefits of dark chocolate for the cardiovascular system, but it has not been established whether dark chocolate intake is associated with the risk of cardiovascular diseases (CVDs). To investigate the causality between dark chocolate intake and the risk of CVDs, a Mendelian randomization (MR) study was conducted. We obtained summary-level data on dark chocolate intake and CVDs from publicly available genome-wide association studies. In this MR study, the main approach was to use a fixed-effect model with inverse variance weighted (IVW) and evaluate the robustness of the results via sensitivity analysis. We found that dark chocolate intake was significantly associated with the reduction of the risk of essential hypertension (EH) (OR=0.73; 95% CI 0.60-0.88; p=1.06x10(-3)), as well as with the suggestive association to the reduced risk of venous thromboembolism (OR=0.69; 95% CI 0.50-0.96; p=2.81x10(-2)). However, no association was found between dark chocolate intake and the other ten CVDs. Our study provides evidence for a causality between dark chocolate intake and a reduced risk of EH, which has important implications for the prevention of EH in the population.