文献类型：期刊文献

英文题名：Progress in the mechanism of autophagy and traditional Chinese medicine herb involved in alcohol-related liver disease

作者：Han, Wenwen[1,2];Li, Haiyu[1,2];Jiang, Hanqi[2];Xu, Hang[2];Lin, Yifeng[2];Chen, Jiahuan[1];Bi, Chenchen[2];Liu, Zheng[3]

机构：[1]Shaoxing Univ, Sch Med, Dept Med Lab, Shaoxing, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Dept Clin Med, Shaoxing, Zhejiang, Peoples R China;[3]Shaoxing Univ, Sch Med, Dept Pharmacol, Shaoxing, Zhejiang, Peoples R China

年份：2023

卷号：11

外文期刊名：PEERJ

收录：SCI-EXPANDED(收录号：WOS:001074470400008)、、Scopus(收录号：2-s2.0-85173854249)、WOS

基金：The following grant information was disclosed by the authors: The Natural Science Foundation of Zhejiang Province: LGF21H180005. The Scientific Research Fund of Shaoxing University: 202110349205xj.

语种：英文

外文关键词：Chinese herbal extracts; Autophagy; Mitophagy; Lipophagy; Alcohol-related liver disease

外文摘要：Alcohol-related liver disease (ALD) is chronic liver damage caused by long-term heavy drinking with, extremely complicated pathogenesis. The current studies speculated that excessive alcohol and its metabolites are the major causes of liver cell toxicity. Autophagy is evolutionarily conserved in eukaryotes and aggravates alcoholic liver damage, through various mechanisms, such as cellular oxidative stress, inflammation, mitochondrial damage and lipid metabolism disorders. Therefore, autophagy plays an critical role in the occurrence and development of ALD. Some studies have shown that traditional Chinese medicine extracts improve the histological characteristics of ALD, as reflected in the improvement of oxidative stress and lipid droplet clearance, which might be achieved by inducing autophagy. This article reviews the mechanisms of quercetin, baicalin, glycycoumarin, salvianolic acid A, resveratrol, ginsenoside rg1, and dihydromyricetin inducing autophagy and their participation in the inhibition of ALD. The regulation of autophagy in ALD by these traditional Chinese medicine extracts provides novel ideas for the treatment of the disease; however, its molecular mechanism needs to be elucidated further.