文献类型：期刊文献

英文题名：Human Endogenous Retroviruses and Toll-Like Receptors

作者：Jin, Xinyi[1];Li, Xueyuan[1];Guan, Fang[1];Zhang, Jianhua[1,2]

机构：[1]Shaoxing Univ, Sch Med, Dept Lab Med, Shaoxing, Peoples R China;[2]Shaoxing Univ, Sch Med, Dept Lab Med, 900 Chengnan Ave, Shaoxing 312000, Peoples R China

年份：0

外文期刊名：VIRAL IMMUNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000870504100001)、、Scopus(收录号：2-s2.0-85148754072)、WOS

基金：This work was supported by grants from the Shaoxing Science and Technology Program of Zhejiang Province (Grant No. 2018C30028).

语种：英文

外文关键词：human endogenous retroviruses; Toll-like receptors; innate immunity

外文摘要：Human endogenous retroviruses (HERVs) are estimated to comprise similar to 8% of the entire human genome, but the vast majority of them remain transcriptionally silent in most normal tissues due to accumulated mutations. However, HERVs can be frequently activated and detected in various tissues under certain conditions. Nucleic acids or proteins produced by HERVs can bind to pattern recognition receptors of immune cells or other cells and initiate an innate immune response, which may be involved in some pathogenesis of diseases, especially cancer and autoimmune diseases. In this review, we collect studies of the interaction between HERV elements and Toll-like receptors and attempt to provide an overview of their role in the immunopathological mechanisms of inflammatory and autoimmune diseases.