文献类型：期刊文献

英文题名：Hyaluronic Acid Poly(glyceryl)(10)-Stearate Derivatives: Novel Emulsifiers for Improving the Gastrointestinal Stability and Bioaccessibility of Coenzyme Q10 Nanoemulsions

作者：Luo, Xiang[1,2];Ao, Sha[1,2];Wu, Hongze[1];McClements, David Julian[3];Fang, Likun[2];Huang, Mengyu[2];Zhou, Yanyan[1];Yin, Xuguang[1];Xi, Meiyang[2];Cai, Tao[2];Zhu, Kewu[1]

机构：[1]Shaoxing Univ, Ctr Drug Delivery Syst Res, Sch Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Sch Chem & Chem Engn, Shaoxing 312000, Zhejiang, Peoples R China;[3]Univ Massachusetts, Dept Food Sci, Biopolymers & Colloids Lab, Amherst, MA 01003 USA

年份：2023

卷号：71

期号：29

起止页码：11180

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001024299700001)、、EI(收录号：20233014453290)、Scopus(收录号：2-s2.0-85165635982)、WOS

基金：The authors gratefully acknowledge the financial support by the Zhejiang Postdoctoral Scientific Research Project (no. ZJ2021024) and the General Scientific Research Projects of Zhejiang Provincial Department of Education (no. 202145959).

语种：英文

外文关键词：hyaluronic acid; poly(glyceryl)(10)-stearate; fish oils; coenzyme Q10; nanoemulsion; bioaccessibility

外文摘要：Fish oils are a rich source of polyunsaturatedfatty acids, includingeicosapentaenoic acid and docosahexaenoic acid, which are reportedto exhibit therapeutic effects in a variety of human diseases. However,these oils are highly susceptible to degradation due to oxidation,leading to rancidity and the formation of potentially toxic reactionproducts. The aim of this study was to synthesize a novel emulsifier(HA-PG10-C18) by esterifying hyaluronic acid with poly(glyceryl)(10)-stearate (PG10-C18). This emulsifier was then used to formulatenanoemulsion-based delivery systems to co-deliver fish oil and coenzymeQ10 (Q10). Q10-loaded fish oil-in-water nanoemulsions were fabricated,and then their physicochemical properties, digestibility, and bioaccessibilitywere measured. The results indicated that the environmental stabilityand antioxidant activity of oil droplets coated with HA-PG10-C18 surpassedthose coated with PG10-C18 due to the formation of a denser interfaciallayer that blocked metal ions, oxygen, and lipase. Meanwhile, thelipid digestibility and Q10 bioaccessibility of nanoemulsions formulatedwith HA-PG10-C18 (94.9 and 69.2%) were higher than those formulatedwith PG10-C18 (86.2 and 57.8%), respectively. These results demonstratedthat the novel emulsifier synthesized in this study could be usedto protect chemically labile fat-soluble substances from oxidativedamage, while still retaining their nutritional value.