文献类型：期刊文献

英文题名：Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment

作者：Ma, Jianyong[1];Wang, Bingzhu[2];Shao, Haibin[2];Zhang, Songou[3];Chen, Xiaozhen[3];Li, Feize[2];Liang, Wenqing[4]

机构：[1]Zhejiang Univ, Shaoxing Peoples Hosp, Dept Gen Practice, Shaoxing Hosp, Shaoxing, Peoples R China;[2]Zhejiang Chinese Med Univ, Zhoushan Hosp Tradit Chinese Med, Internal Med Integrated Tradit Chinese & Western, Zhoushan 316000, Peoples R China;[3]Shaoxing Univ, Coll Med, Shaoxing, Peoples R China;[4]Zhejiang Chinese Med Univ, Med Res Ctr, Zhoushan Hosp Tradit Chinese Med, 355 Xingiao Rd, Zhoushan 316000, Peoples R China

年份：2022

卷号：29

期号：1

起止页码：1457

外文期刊名：DRUG DELIVERY

收录：SCI-EXPANDED(收录号：WOS:000792519400001)、、Scopus(收录号：2-s2.0-85129999017)、WOS

基金：This work was supported by Public Technology Applied Research Projects of Zhejiang Province (LGF22H060023 to WQL), Medical and Health Research Project of Zhejiang Province (2022KY433 to WQL), and Traditional Chinese Medicine Science and Technology Projects of Zhejiang Province (2022ZB382 to WQL).

语种：英文

外文关键词：Hydrogel; stimuli-responsive; liver cancer; chemotherapy; ligands; polymer

外文摘要：The systemic drug has historically been preferred for the treatment of the majority of pathological conditions, particularly liver cancer. Indeed, this mode of treatment is associated with adverse reactions, toxicity, off-target accumulation, and rapid hepatic and renal clearance. Numerous efforts have been made to design systemic therapeutic carriers to improve retention while decreasing side effects and clearance. Following systemic medication, local administration of therapeutic agents allows for higher 'effective' doses with fewer side effects, kidney accumulation, and clearance. Hydrogels are highly biocompatible and can be used for both imaging and therapy. Hydrogel-based drug delivery approach has fewer side effects than traditional chemotherapy and can deliver drugs to tumors for a longer time. The chemical and physical flexibility of hydrogels can be used to achieve disease-induced in situ accumulation as well as subsequent drug release and hydrogel-programmed degradation. Moreover, they can act as a biocompatible depot for localized chemotherapy when stimuli-responsive carriers are administrated. Herein, we summarize the design strategies of various hydrogels used for localized chemotherapy of liver cancer and their delivery routes, as well as recent research on smart hydrogels.