文献类型：期刊文献

英文题名：Citric acid crosslinked chitosan/poly(ethylene oxide) composite nanofibers fabricated by electrospinning and thermal treatment for controlled drug release

作者：Xing, Guiying[1];Shao, Linjun[2];Du, Yijun[2];Tao, Hongyu[2];Qi, Chenze[2]

机构：[1]Shaoxing Univ, Sch Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Zhejiang Key Lab Alternat Technol Fine Chem, Shaoxing 312000, Zhejiang, Peoples R China

年份：2021

卷号：28

期号：2

起止页码：961

外文期刊名：CELLULOSE

收录：SCI-EXPANDED(收录号：WOS:000591293300001)、、EI(收录号：20204709515419)、Scopus(收录号：2-s2.0-85096326389)、WOS

基金：The authors acknowledge the financial support from the National Natural Science Foundation of China (No. 11705117, 11905132 and 11975157). We greatly thank Prof. Zhenping Chen and Dr. Haiyang Dai (Zhengzhou University of Light Industry) for PALS analyses.

语种：英文

外文关键词：Chitosan nanofiber; Electrospinning; Free volume; Drug carrier; Controlled drug release

外文摘要：A nontoxic multicarboxylic acid (critic acid) was incorporated into the chitosan/poly(ethylene oxide) composite nanofibers by electrospinning. Critic acid was used to crosslink the chitosan molecules inside the composite nanofibers at elevated temperature, which were characterized by FT-IR and XPS analyses. By increasing the critic acid loading and annealing temperature, the solvent resistance and mechanical properties of these composite nanofibers could be significantly improved. Aspirin, a model drug, has been incorporated into the composite nanofibers and the corresponding drug release performances in PBS solution were evaluated. With the increasing of annealing temperature, the drug release rate of the composite nanofibers was decreasing, which could be ascribed to the reduced swelling ratio and concentration of free volume holes in composite nanofibers. Moreover, the cumulative released aspirin amount in certain release time could be finely tuned by adjusting the initial aspirin loading in the composite nanofibers.