文献类型：期刊文献

英文题名：Cantharidin as an Antitumor Agent: A Retrospective Review

作者：Deng, L. P.[1,2];Dong, J.[1];Cai, H.[1,3];Wang, W.[4]

机构：[1]Shaoxing Univ, Chem & Chem Engn Inst, Dept Pharmacol, Shaoxing 312000, Zhejiang, Peoples R China;[2]Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmaceut Biol, D-55128 Mainz, Germany;[3]Ningbo Univ, Fac Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China;[4]Zhejiang Supor Pharmaceut, Shaoxing 312000, Zhejiang, Peoples R China

年份：2013

卷号：20

期号：2

起止页码：159

外文期刊名：CURRENT MEDICINAL CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000316607200001)、、Scopus(收录号：2-s2.0-84877959384)、WOS

基金：This project is funded by the Natural Science Foundation of Zhejiang Province, China (Y2100872 and LY12E03001), National Natural Science Foundation of China (No. 20974063), and supported by the National Science Foundation for Young Scholars of China (Grant No. 81202411).

语种：英文

外文关键词：Cantharidin; norcantharidin; antitumor; structure-activity relationship

外文摘要：This review summarizes the progress that has been made recently in the medicinal chemistry of cantharidin, a potent antitumor agent from traditional Chinese medicine. Thousands of analogs have been synthesized on the basis of cantharidin, a part of which shows excellent properties, in particular, norcantharidin and norcantharimide. Despite the enormous efforts made, the intriguing bioactivities, mechanism, indications, and their interplay are still ill-defined. This review provides our up-to-date understanding in connection with the therapeutic use, mechanism, structure-activity relationship (SAR) and interesting properties of cantharidin analogs. Considerable development in the design of cantharidin analogs, in combination with mechanistic studies, has laid a foundation for transforming novel antitumor drugs into the clinic.