文献类型：期刊文献

英文题名：Functional and therapeutic significant of heat-shock protein 90 (HSP90) in reproductive cancers

作者：He, Ben-Zhen[1];Wang, Liang[1]

机构：[1]Shaoxing Univ, Shaoxing Municipal Hosp, Affiliated Hosp, Dept Radiol, Shaoxing, Zhejiang, Peoples R China

年份：2024

外文期刊名：CLINICAL & TRANSLATIONAL ONCOLOGY

收录：SCI-EXPANDED(收录号：WOS:001329532900002)、、WOS

语种：英文

外文关键词：Reproductive cancers; Cervical carcinoma; Endometrial carcinoma; Ovarian carcinoma; HSP90

外文摘要：Reproductive cancers, such as ovarian, cervical, and endometrial carcinomas, have a poor prognosis in metastatic stages. Researchers are continuously seeking improved and safer methods to target cancer-related oncoproteins, addressing the limitations of current treatments, including their limited effectiveness, drug resistance, and off-target effects. Recent advancements in understanding the molecular mechanisms involved in the progress of reproductive cancers have provided valuable insights into potential targeted therapies. By engaging with oncoproteins and co-chaperones, heat-shock protein 90 (HSP90) regulates signaling networks and fixes protein folding errors in cancer cells. The potential of HSP90 inhibition as cancer-targeted treatments is underscored by the continuous discovery and testing of novel HSP90-targeted molecules for their antitumor properties in preclinical and clinical settings. Therefore, this study aims to shed light on the mechanism and recent research breakthroughs of HSP90, as well as provide an in-depth review of their therapeutic potential in reproductive cancers.