文献类型：期刊文献

英文题名：Molecular mechanism and therapeutic strategy of bile acids in Alzheimer's disease from the emerging perspective of the microbiota-gut-brain axis

作者：Wu, Menglu[1,2];Cheng, Yongyi[2];Zhang, Ruolin[2];Han, Wenwen[2];Jiang, Hanqi[2];Bi, Chenchen[2];Zhang, Ziyi[2];Ye, Mengfei[3];Lin, Xiuqin[1];Liu, Zheng[2,4]

机构：[1]Shaoxing Univ, Shaoxing Peoples Hosp 7, Affiliated Mental Hlth Ctr, Clin Lab,Med Coll, Shaoxing, Zhejiang, Peoples R China;[2]Shaoxing Univ, Med Sch, Sci Res Ctr, Dept Behav Neurosci, Shaoxing, Zhejiang, Peoples R China;[3]Shaoxing Univ, Shaoxing Peoples Hosp 7, Affiliated Mental Hlth Ctr, Dept Psychiat,Med Coll, Shaoxing, Peoples R China;[4]Shaoxing Univ, Sch Med, Dept Pharmacol, Shaoxing, Zhejiang, Peoples R China

年份：2024

卷号：178

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：SCI-EXPANDED(收录号：WOS:001286384200001)、、Scopus(收录号：2-s2.0-85199982614)、WOS

基金：This work was funded by the Zhejiang Medical and Health Science and Technology Project (Nos. 2023KY1271, 2024KY484) , the Shaoxing Health Science and Technology Project (Nos. 2023SKY072, 2023SKY073) , the Science and Technology Planning Project of Shaoxing City, China (No. 2023A14030) , and the Shaoxing Seventh People's Hospital (No. 2022Q03) .

语种：英文

外文关键词：Alzheimer's disease; bile acids; microbiota-gut-brain axis; molecular mechanism; therapeutic strategy

外文摘要：Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-beta outside neurons and Tau protein inside neurons. Various pathological mechanisms are implicated in AD, including brain insulin resistance, neuroinflammation, and endocrinal dysregulation of adrenal corticosteroids. These factors collectively contribute to neuronal damage and destruction. Recently, bile acids (BAs), which are metabolites of cholesterol, have shown neuroprotective potential against AD by targeting the above pathological changes. BAs can enter the systematic circulation and cross the blood-brain barrier, subsequently exerting neuroprotective effects by targeting several endogenous receptors. Additionally, BAs interact with the microbiota-gut-brain (MGB) axis to improve immune and neuroendocrine function during AD episodes. Gut microbes impact BA signaling in the brain through their involvement in BA biotransformation. In this review, we summarize the role and molecular mechanisms of BAs in AD while considering the MGB axis and propose novel strategies for preventing the onset and progression of AD.