文献类型：期刊文献

英文题名：CD14-159 and-260 gene polymorphisms are associated with HBV-related cirrhotic injury in Chinese Han patients

作者：Yan, Chun-Gen[1];Ren, Guang-Yuan[2];Wang, Feng[3];Zhu, Dong-Fang[1];Zhuang, Yan[4]

机构：[1]Shaoxing Univ, Sch Med, Dept Internal Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Dept Surg, Shaoxing 312000, Zhejiang, Peoples R China;[3]Sixth Hosp Shanghai Jiaotong Univ, Dept Nephrol, Shanghai 200233, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Med, Shanghai Ruijin Hosp, Dept Infect, Shanghai 200025, Peoples R China

年份：2008

卷号：51

期号：2

起止页码：94

外文期刊名：CHINESE JOURNAL OF PHYSIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000254968400005)、、WOS

语种：英文

外文关键词：CD14; toll-like receptor 4; liver cirrhosis; polymorphism

外文摘要：The present study aimed to investigate the association between TLR4 mutations (Asp299Gly and Thr3991le) and CD14 polymorphisms (base pair -159 and -260) with HBV-related cirrhosis in Chinese Han patients. By use of a polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis technique, we genotyped Toll-like receptor 4 (TLR4) Asp299Gly and Thr39911e and CD14-159 and -260 polymorphisms in 110 HBV-related cirrhotic patients and 110 healthy controls from the Chinese Han population. We found significant differences in the genotypes and allele frequencies of CD14-159 (but not -260) between healthy controls and liver cirrhotic patients, and both the CD14-159 and -260 genotypes were significantly different among Child-Pugh grades in cirrhotic patients. No TLR4 Asp299Gly and Thr3991le mutations were detected in any cirrhotic patients or healthy controls in the Chinese Han population. These findings indicated that the polymorphisms of CD14, but not TLR4 Asp299Gly and Thr3991le mutations, may be an important genetic factor for HBV-related cirrhotic injury in the Chinese Han population.