文献类型：期刊文献

中文题名：微波辐射法合成壳聚糖单胍盐酸盐抗菌剂的研究

英文题名：Research on synthesis of antibacterial chitosan guanidine hydrochloride under microwave irradiation

作者：赵雪[1,2]

机构：[1]绍兴文理学院纺织服装学院;[2]浙江省清洁染整技术研究重点实验室

年份：2017

卷号：48

期号：11

起止页码：11157

中文期刊名：功能材料

外文期刊名：Journal of Functional Materials

收录：CSTPCD、、北大核心2014、CSCD_E2017_2018、Scopus、北大核心、CSCD

基金：绍兴文理学院科研启动经费资助项目(20135008);绍兴市科技计划公益技术应用研究资助项目(2014B70013)

语种：中文

中文关键词：壳聚糖单胍盐酸盐;微波辐射;合成;抗菌活性

外文关键词：chitosan guanidine hydrochloride;microwave irradiation;synthesis;antibacterial activity

中文摘要：以壳聚糖,三氧化硫脲和盐酸为反应原料,采用微波辐射的方法合成壳聚糖单胍盐酸盐。采用正交实验法通过研究反应温度,壳聚糖和三氧化硫脲的摩尔比以及反应时间对产率和胍取代度的影响确定了最佳合成工艺。采用红外光谱和核磁共振波谱仪对壳聚糖单胍盐的结构进行了表征。测试了产品的最低抑菌浓度。结果表明,采用微波辐射的方式合成壳聚糖单胍盐酸盐较传统的合成方法反应速度提高了6倍,相比于壳聚糖,壳聚糖单胍盐酸盐具有更为优异的抗菌活性。

外文摘要：Chitosan guanidine hydrochloride was synthesized by reacting chitosan,thiourea trioxide and hydrochloric acid under microwave irradiation.The influence of reaction temperature,molar ratio of chitosan and thiourea trioxide and microwave heating time on yield and the degree of substitution was studied by orthogonal experimental method,and optimal conditions were identified.The representative microwave synthesized chitosan guanidine hydrochloride was characterized by FT-IR and 13CNMR,taking chitosan as a reference.The antimicrobial activities of chitosan guanidine hydrochloride were measured by means of the minimal inhibition concentration（MIC）.The results show that the microwave irradiation method can increase the reaction rate by six times over the conventional method.Chitosan guanidine hydrochloride is effective of bacteriostasis.Compared with chitosan,chitosan guanidine hydrochloride had much better antibacterial activity.