文献类型：期刊文献

英文题名：Association of the location and initial degree of malignant central airway stenosis with the risk of severe restenosis after interventional bronchoscopy

作者：Wang, Saibin[1];Zhou, Renzhi[1];Zhu, Siyao[2];Yan, Dan[1]

机构：[1]Jinhua Municipal Cent Hosp, Dept Resp Med, 365 East Renmin Rd, Jinhua 321000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Shaoxing 312000, Zhejiang, Peoples R China

年份：2021

卷号：21

期号：1

外文期刊名：BMC PULMONARY MEDICINE

收录：SCI-EXPANDED(收录号：WOS:000708466500003)、、Scopus(收录号：2-s2.0-85117389552)、WOS

基金：This study was supported by the Medical and Health Science and Technology Plan Project of Zhejiang Province (No. 2018RC079, 2022495999), Youth Research Fund of Jinhua Municipal Central Hospital (No. JY2017-2-05), and the Science and Technology Project of Jinhua City (No. 2020XG-15). Zhejiang health and Health Committee, Jinhua Municipal Central Hospital and Jinhua Science and Technology Bureau provided funding but had no role in study design or collection, analysis or interpretation, nor in writing of the manuscript.

语种：英文

外文关键词：Malignant central airway stenosis; Restenosis; Bronchoscopy; Lung cancer

外文摘要：Background Therapeutic bronchoscopy is one of the effective methods in the treatment and management of malignant central airway stenosis (MCAS). However, restenosis after therapeutic bronchoscopy frequently occurs and severe restenosis (SR) can be life-threatening. Therefore, this study aimed at investigating the risk factors for SR after therapeutic bronchoscopy. Methods The data of 233 consecutive cases with MCAS who were subjected to therapeutic bronchoscopy between 2015 and 2020 at a tertiary hospital were collected. Patients were divided into SR group and non-SR during 6 months after therapeutic bronchoscopy. Multiple logistic regression analysis was performed to determine the risk factors for SR. Results SR during 6 months after therapeutic bronchoscopy occurred in 39.5% (92/233) of patients. The location and the initial degree of MCAS were associated with SR, as assessed by multiple logistic regression analysis (P < 0.05). The risk of SR after therapeutic bronchoscopy in the left main bronchus, right main bronchus, and right intermediate bronchus increased, compared to the risk when of MCAS was located in the trachea (OR (95% CI) of 8.821 (1.850-25.148), 6.583 (1.791-24.189), and 3.350 (0.831-13.511), respectively). In addition, the initial degree of MCAS was positively associated with an increased risk of SR (OR 1.020; 95% CI 1.006-1.035). Conclusions MCAS located in the left main bronchus, right main bronchus and right intermediate bronchus, as well as the higher initial degree of MCAS were independent risk factors for SR during 6 months after therapeutic bronchoscopy.