文献类型：期刊文献

英文题名：Triptolide activates the Nrf2 signaling pathway and inhibits the NF-κB signaling pathway to improve Alzheimer disease

作者：He, Zuoting[1];Botchway, Benson O. A.[2,3];Zhang, Yong[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Zhejiang 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China;[3]Bupa Cromwell Hosp, London, England

年份：2023

外文期刊名：METABOLIC BRAIN DISEASE

收录：SCI-EXPANDED(收录号：WOS:001063530800001)、、Scopus(收录号：2-s2.0-85168961178)、WOS

基金：We thank Shaoxing University for infrastructure support.

语种：英文

外文关键词：Alzheimer disease; Triptolide; Nrf2 signaling pathway; NF-kappa B signaling pathway; Inflammation

外文摘要：Alzheimer disease (AD) is a common neurodegenerative disease with pathological features of accumulated amyloid plaques, neurofibrillary tangles, and the significant inflammatory environment. These features modify the living microenvironment for nerve cells, causing the damage, dysfunction, and death. Progressive neuronal loss directly leads to cognitive decline in AD patients and is closely related to brain inflammation. Therefore, impairing inflammation via signaling pathways may facilitate either the prevention or delay of the degenerative process. Triptolide has been evidenced to possess potent anti-inflammatory effect. In this review, we elaborate on two signaling pathways (the NF-.B and Nrf2 signaling pathways) that are involved in the anti-inflammatory effect of triptolide.