文献类型：期刊文献

英文题名：Muscone Can Improve Spinal Cord Injury by Activating the Angiogenin/Plexin-B2 Axis

作者：Zhou, Yu[1];Guo, Shitian[2];Botchway, Benson O. A.[3];Zhang, Yong[1];Jin, Tian[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Sch Med, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China;[2]Hangzhou Normal Univ, Sch Clin Med, Hangzhou, Peoples R China;[3]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China

年份：0

外文期刊名：MOLECULAR NEUROBIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000825774000001)、、Scopus(收录号：2-s2.0-85133720509)、WOS

基金：The Natural Science Foundation of Zhejiang Province supported this work (no. LY19H170001).

语种：英文

外文关键词：Muscone; Angiogenin; plexin-B2 axis; Spinal cord injury; Cell proliferation; Anti-inflammation

外文摘要：Spinal cord injury (SCI) is a devastating neurological disorder that usually damages sensorimotor and autonomic functions. Signaling pathways can play a key role in the repair process of SCI. The plexin-B2 acts as a receptor for angiogenin and mediates ribosomal RNA transcription, influencing cell survival and proliferation. Protein kinase B serine/threonine kinase interacts with angiogenin to form a positive feedback effect. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor can induce angiogenin nuclear translocation. Moreover, the BDNF can promote the secretion of angiogenin. Interestingly, all of them can activate the angiogenin/plexin-B2 axis. Muscone has anti-inflammatory and proliferative features as it can inhibit nuclear transcription factor kappa-B (NF-kappa B) and activate the angiogenin/plexin-B2 axis, thus being significant agent in the SCI repair process. Herein, we review the potential mechanism of angiogenin/plexin-B2 axis activation and the role of muscone in SCI treatment. Muscone may attenuate inflammatory responses and promote neuronal regeneration after SCI.