文献类型：期刊文献

中文题名：Bcl-2和Bax蛋白在人早孕胎盘绒毛和蜕膜组织中的表达

英文题名：EXPRESSIONS OF Bcl-2 AND Bax PROTEINS IN CHORIONIC VILLUS AND DECIDUAL TISSUE OF HUMAN PLACENTA DURING EARLY PREGNANCY

作者：张金萍[1];刘学红[1];张泳[1];周夫群[2];朱颖飞[1]

机构：[1]绍兴文理学院医学院组织学与胚胎学教研室;[2]绍兴市妇女儿童医院妇产科

年份：2008

卷号：39

期号：4

起止页码：590

中文期刊名：解剖学报

外文期刊名：Acta Anatomica Sinica

收录：CSTPCD、、北大核心2004、Scopus、CSCD2011_2012、北大核心、CSCD

语种：中文

中文关键词：Bcl-2蛋白;Bax蛋白;早孕;绒毛;蜕膜;免疫组织化学;人

外文关键词：Bcl-2 protein; Bax protein; Early pregnancy; Chorionic villi; Decidua; lmmunohistochemistry; Human

中文摘要：目的探讨Bcl-2和Bax蛋白在人早孕绒毛和蜕膜组织中的表达及其意义。方法应用免疫组织化学ABC法检测Bcl-2和Bax蛋白在孕5～7周绒毛和蜕膜组织细胞中的表达,用真彩色病理图像分析系统4.0图像分析软件测定Bcl-2和Bax蛋白表达的积分吸光度值。结果Bc1-2蛋白主要分布于孕5～7周绒毛合体滋养层细胞、蜕膜细胞的细胞质和细胞核中,蛋白表达积分吸光度值依次降低,其差异无统计学意义（P〉0.05）。Bax蛋白在孕5～7周绒毛细胞滋养层细胞、合体滋养层细胞中均未见表达;孕6周,Bax蛋白表达于极少部分蜕膜细胞的细胞质中。结论Bc1-2和Bax蛋白在人早孕过程中参与了绒毛滋养层细胞增殖和分化、子宫内膜蜕膜化的过程,在绒毛的发生、发育、胎盘形成和组织结构改建及功能完善等方面发挥着重要作用。

外文摘要：Objective To study the expressions of Bcl-2 and Bax proteins in human chorionic villus and decidual tissue during early pregnancy. Methods The expressions of Bcl-2 and Bax proteins in the cells of human chorionic villus and decidua were observed by immunohistochemistry（ABC） from the 5th to the 7th week in early pregnancy. Integral absorbances （IA） of Bcl-2 and Bax proteins were detected by using special image analysis software. Results Bcl-2 protein expressed in all syncytiotrophoblast cells and decidual cells, and its protein integral absorbance decreased with time. The difference between any two groups was not significant statistically （ P 〉 0.05）. From the fifth week to seventh week, no expression of Bax protein observed in syncytiotrophoblast and cytotrophoblastic cells. Bax protein expressed in a few the decidual cells in the sixth week of early pregnancy. Conclusion Bcl-2 and Bax proteins express in early pregnancy, which take part in the multiplication and differentiation of trophoblast cells, and womb decidualization during early pregnancy. They play an important role in the development and morphogenesis of villus, the rebuilding of tissue structure and the functional consummation of placenta.