文献类型：期刊文献

英文题名：Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-κB Signaling Pathway

作者：Lin, Kexin[1];Zhang, Yong[1];Shen, Yanyang[1];Xu, Yiqin[1];Huang, Min[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China

年份：2024

卷号：26

期号：1

外文期刊名：NEUROMOLECULAR MEDICINE

收录：SCI-EXPANDED(收录号：WOS:001251507000001)、、Scopus(收录号：2-s2.0-85196489467)、WOS

语种：英文

外文关键词：Hydrogen sulfide; Spinal cord injury; Free radicals; p38MAPK/mTOR/NF-kappa B signaling pathway; Reactive oxygen species

外文摘要：Spinal cord injury (SCI) causes irreversible cell loss and neurological dysfunctions. Presently, there is no an effective clinical treatment for SCI. It can be the only intervention measure by relieving the symptoms of patients such as pain and fever. Free radical-induced damage is one of the validated mechanisms in the complex secondary injury following primary SCI. Hydrogen sulfide (H2S) as an antioxidant can effectively scavenge free radicals, protect neurons, and improve SCI by inhibiting the p38MAPK/mTOR/NF-kappa B signaling pathway. In this report, we analyze the pathological mechanism of SCI, the role of free radical-mediated the p38MAPK/mTOR/NF-kappa B signaling pathway in SCI, and the role of H2S in scavenging free radicals and improving SCI.