文献类型：期刊文献

英文题名：Photocatalyst-, metal- and additive-free regioselective radical cascade sulfonylation/cyclization of benzimidazole derivatives with sulfonyl chlorides induced by visible light

作者：Sun, Bin[1];Tian, Hai-Xia[2];Ni, Zhi-Gang[3];Huang, Pan-Yi[2];Ding, Hao[2];Li, Bing-Qian[2];Jin, Can[1,2];Wu, Chun-Lei[4];Shen, Run-Pu[4]

机构：[1]Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China;[2]Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China;[3]Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Minist Educ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 311121, Peoples R China;[4]Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Shaoxing 312000, Peoples R China

年份：0

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：SCI-EXPANDED(收录号：WOS:000803092000001)、、EI(收录号：20222412225524)、Scopus(收录号：2-s2.0-85131715227)、WOS、CCR-EXPANDED(收录号：WOS:000803092000001)

基金：This work was supported by the National Natural Science Foundation of China (22078299 and 22108250), the Natural Science Foundation of Zhejiang Province (LY21B060005 and LQ20B060007), the Opening Project of Zhejiang Engineering Research Center of Fat-soluble Vitamin (202101 and 202201), and the Research Project of Zhejiang Provincial Department of Education (Y201840109). We are also grateful to the College of Pharmaceutical Sciences, Zhejiang University of Technology, and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals for the financial help.

语种：英文

外文摘要：Herein, an environmentally friendly and practical protocol for the visible-light-triggered regioselective radical cascade sulfonylation/cyclization of unactivated alkenes towards the synthesis of polycyclic benzimidazoles containing the sulfone group has been developed. Notably, the control experiments demonstrated that a radical pathway was involved in this reaction, and a sulfonyl radical center was initially generated via self-homolysis of sulfonyl chloride upon irradiation. Moreover, this protocol features a wide substrate scope, high atom economy, and excellent regioselectivity, and is easy to scale up.