文献类型：期刊文献

英文题名：Synchronous triple squamous cell carcinomas of the stomach, skin and gingiva with liver, lung, spleen, kidney, bone and brain metastases: A case report

作者：Tang, Mengyao[1];Chen, Xiuxia[2];Liu, Linger[3];Chen, Baisong[3];Han, Wenwen[1];Zhao, Xiaofeng[1];Chen, Yao[3]

机构：[1]Shaoxing Univ, Sch Med, Dept Internal Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhuji Peoples Hosp Zhejiang Prov, Dept Pathol, Zhuji 311800, Zhejiang, Peoples R China;[3]Shaoxing Univ, Zhuji Peoples Hosp Zhejiang Prov, Dept Oncol, 9 Jianmin Rd, Zhuji 311800, Zhejiang, Peoples R China

年份：2025

卷号：29

期号：6

外文期刊名：ONCOLOGY LETTERS

收录：SCI-EXPANDED(收录号：WOS:001468516700001)、、Scopus(收录号：2-s2.0-105003437231)、WOS

基金：Not applicable.

语种：英文

外文关键词：synchronous; metastases; multiple squamous cell carcinomas; cutaneous squamous cell carcinoma; gastric squamous cell carcinoma; gingival malignancy; camrelizumab

外文摘要：Synchronous multiple squamous cell carcinomas (SCCs) of the stomach, skin and gingiva are very rare. A 67-year-old male patient was admitted to hospital with progressive chest tightness and fatigue, accompanied by melena. Gastric and dermal biopsies revealed SCCs, and it was considered that triple primary SCCs of the skin, stomach and gingiva had metastasized to the cerebrum, liver, lung, spleen, kidney, bone and subcutaneous tissue. The patient received one cycle of camrelizumab, carboplatin and nab-paclitaxel, followed by two cycles of camrelizumab monotherapy and best supporting care. However, his performance status deteriorated, and he had a very poor survival outcome, succumbing 3 months after diagnosis. Discriminating pathologically between synchronous SCCs in individual organs as metastases or primaries is challenging. In the present case, a diagnosis of triple primary SCCs of the skin, stomach and gingiva with multiple organ metastases was made based on epidemiologic features and clinical presentation. The results of the present case report suggested that anti-programmed death 1 antibodies combined with platinum-based chemotherapy may be a treatment option for metastatic SCC.